Document Detail

An analysis of signatures of selective sweeps in natural populations of the house mouse.
MedLine Citation:
PMID:  16421176     Owner:  NLM     Status:  MEDLINE    
Population and locus-specific reduction of variability of polymorphic loci could be an indication of positive selection at a linked site (selective sweep) and therefore point toward genes that have been involved in recent adaptations. Analysis of microsatellite variability offers a way to identify such regions and to ask whether they occur more often than expected by chance. We studied four populations of the house mouse (Mus musculus) to assess the frequency of such signatures of selective sweeps under natural conditions. Three samples represent the subspecies Mus m. dometicus [corrected] and came from Germany, France, and Cameroon. One sample came from Kazakhstan and constitutes a population of the subspecies Mus m. [corrected] musculus. Mitochondrial D-loop sequences from all animals confirm their respective assignments. Approximately 200 microsatellite loci were typed for up to 60 unrelated individuals from each population and evaluated for signs of selective sweeps on the basis of Schlötterer's ln RV and ln RH statistics. Our data suggest that there are slightly more signs of selective sweeps than would have been expected by chance alone in each of the populations and also highlights some of the statistical challenges faced in genome scans for detecting selection. Single-nucleotide polymorphism typing of one sweep signature in the M. m. domesticus populations around the beta-defensin 6 locus confirms a lowered nucleotide diversity in this region and limits the potential sweep region to about 20 kb. However, no amino acid exchange has occurred in the coding region when compared to M. m. musculus. If this sweep signature is due to a recent adaptation, it is expected that a regulatory change would have caused it. Our data provide a framework for conducting a systematic whole genome scan for signatures of selective sweeps in the mouse genome.
Sonja Ihle; Iary Ravaoarimanana; Meike Thomas; Diethard Tautz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-18
Journal Detail:
Title:  Molecular biology and evolution     Volume:  23     ISSN:  0737-4038     ISO Abbreviation:  Mol. Biol. Evol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-09     Completed Date:  2007-03-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8501455     Medline TA:  Mol Biol Evol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  790-7     Citation Subset:  IM    
Institut für Genetik der Universität zu Köln, Köln, Germany.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AM182648;  AM182649;  AM182650;  AM182651;  AM182652;  AM182653;  AM182654;  AM182655;  AM182656;  AM182657;  AM182658;  AM182659;  AM182660;  AM182661;  AM182662;  AM182663;  AM182664;  AM182665;  AM182666;  AM182667;  AM182668;  AM182669;  AM182670;  AM182671;  AM182672;  AM182673;  AM182674;  AM182675;  AM182676;  AM182677;  AM182678;  AM182679;  AM182680;  AM182681;  AM182682;  AM182683;  AM182684;  AM182685;  AM182686;  AM182687;  AM182688;  AM182689;  AM182690;  AM182691;  AM182692;  AM182693;  AM182694;  AM182695;  AM182696;  AM182697;  AM182698;  AM182699;  AM182700;  AM182701;  AM182702;  AM182703;  AM182704;  AM182705;  AM182706;  AM182707;  AM182708;  AM182709;  AM182710;  AM182711;  AM182712;  AM182713;  AM182714;  AM182715;  AM182716;  AM182717;  AM182718;  AM182719;  AM182720;  AM182721;  AM182722;  AM182723;  AM182724;  AM182725;  AM182726;  AM182727;  AM182728;  AM182729;  AM182730;  AM182731;  AM182732;  AM182733;  AM182734;  AM182735;  AM182736;  AM182737;  AM182738;  AM182739;  AM182740;  AM182741;  AM182742
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MeSH Terms
Amino Acid Sequence
Base Sequence
Evolution, Molecular*
Genetics, Population*
Microsatellite Repeats / genetics
Molecular Sequence Data
Selection, Genetic*
Sequence Alignment
beta-Defensins / genetics
Reg. No./Substance:
Erratum In:
Mol Biol Evol. 2006 May;23(5):1095

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