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The analysis of second-trimester triple screening for Down syndrome in Chinese normal singleton pregnancies.
MedLine Citation:
PMID:  23057770     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and objectives. The study aimed to compare the α fetoprotein (AFP), total β-human chorionic gonadotropin (hCG), and unconjugated estriol (uE3) levels in the second-trimester triple screening for Down syndrome with different regions, and to analyse the related factors that influenced the screening performance. Materials and methods. The study was conducted between February 2007 and November 2010 in Beijing Tongren Hospital, P. R. China. Data derived from 7,647 normal singleton pregnancies between 14 and 21 weeks of gestation were examined. The regressed median values in different gestational ages were compared with earlier published data from other regions. The distribution of median values and multiples of median (MoM) of AFP, hCG and uE3 according to maternal age and weight in normal pregnancies were described. Statistic parameters for AFP, hCG, and uE3 (based on log(10) MoM values) were compared with earlier published data from other studies. Results. There were significantly increasing trends for AFP (p < 0.001) and uE3 (p < 0.001), and a significantly decreasing trend for hCG (p < 0.001) in the second trimester. There were significantly decreasing trends with increasing maternal weight for all the markers and their MoMs (p < 0.001). The distribution of the log(10) MoM marker values were Gaussian for the three parameters. Conclusions. Ethnic and laboratory variance should be taken into account in the second trimester triple screening for Down syndrome. The parameters of maternal serum markers should be calculated using local data, and the algorithm modified to match the screening achievable for the local population.
Authors:
Xiaohua Wan; Jiangping Wen; Xin Song; Yongjun Guo; Xiangyi Liu; Benshan Yang; Xinxin Lu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  -     ISSN:  1502-7686     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Clinical Laboratory , Beijing Tongren Hospital, Capital Medical University, Beijing , P. R. China.
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