| An analysis of the negative inotropic action of somatostatin. | |
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MedLine Citation:
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PMID: 465878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 Somatostatin (SS) was evaluated as a chronotropic and inotropic agent in isolated spontaneously beating auricles of rats, rabbits and guinea-pigs.2 SS was completely inactive in rat and rabbit auricles but exerted a dose-dependent, negative inotropic effect in guinea-pig auricles in concentrations between 1.5 x 10(-8) to 1.2 x 10(-6) M.3 The negative inotropic effect of SS (6.0 x 10(-8) and 3.0 x 10(-7) M) was not inhibited by a mixture of antagonists containing practolol (7.9 x 10(-6) M), phentolamine (3.5 x 10(-7) M), methysergide (2.8 x 10(-7) M), diphenhydramine (3.9 x 10(-5) M), cimetidine (4.0 x 10(-5) M) atropine (3.4 x 10(-7) M) and indomethacin (1.4 x 10(-5) M).4 The negative inotropic effect of SS was greatly potentiated by reduction in the Ca(2+) concentration of the medium from 5.0 to 1.25 mM.5 On a molar basis, SS was equipotent with acetylcholine (ACh) as a negative inotropic agent in the guinea-pig auricles.6 SS (6.0 x 10(-8) and 6.0 x 10(-7) M) was found to inhibit selectively the positive inotropic action of neurotensin (NT) in guinea-pig but not in rat auricles.7 The inhibitory action of SS against NT was independent of its negative inotropic action.8 These results suggest that SS produces its negative inotropic action by interacting with specific receptors presumably located in the cell membrane of guinea-pig atria. The interaction between SS and its receptor may cause a decreased Ca(2+) diffusion and/or transport into the atrial cells. The physiological and pharmacological significance of these results is discussed. |
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Authors:
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R Quirion; D Regoli; F Rioux; S St-Pierre |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 66 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1979 Jun |
Date Detail:
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Created Date: 1979-10-26 Completed Date: 1979-10-26 Revised Date: 2010-09-02 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 251-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Atropine / pharmacology Calcium / pharmacology Cimetidine / pharmacology Diphenhydramine / pharmacology Guinea Pigs Indomethacin / pharmacology Methysergide / pharmacology Myocardial Contraction / drug effects* Phentolamine / pharmacology Practolol / pharmacology Rabbits Rats Somatostatin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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361-37-5/Methysergide; 50-60-2/Phentolamine; 51-55-8/Atropine; 51-84-3/Acetylcholine; 51110-01-1/Somatostatin; 51481-61-9/Cimetidine; 53-86-1/Indomethacin; 58-73-1/Diphenhydramine; 6673-35-4/Practolol; 7440-70-2/Calcium |
| Comments/Corrections | |
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