Document Detail


Is analysis of lower esophageal sphincter vector volumes of value in diagnosing gastroesophageal reflux disease?
MedLine Citation:
PMID:  12508377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: With successful surgical treatment of gastroesophageal reflux disease (GERD), there is interest in understanding the anti-reflux barrier and its mechanisms of failure. To date, the potential use of vector volumes to predict the DeMeester score has not been adequately explored. METHODS: 627 patients in the referral database received esophageal manometry and ambulatory 24-hour pH monitoring. Study data included LES resting pressure (LESP), overall LES length (OL) and abdominal length (AL), total vector volume (TVV) and intrabdominal vector volume (IVV). RESULTS: In cases where LESP, TVV or IVV were all below normal, there was an 81.4 % probability of a positive DeMeester score. In cases where all three were normal, there was an 86.9 % probability that the DeMeester score would be negative. Receiver-operating characteristics (ROC) for LESP, TVV and IVV were nearly identical and indicated no useful cut-off values. Logistic regression demonstrated that LESP and IVV had the strongest association with a positive DeMeester score; however, the regression formula was only 76.1 % accurate. CONCLUSION: While the indices based on TVV, IVV and LESP are more sensitive and specific, respectively, than any single measurement, the measurement of vector volumes does not add significantly to the diagnosis of GERD.
Authors:
Robert E Marsh; Christopher L Perdue; Ziad T Awad; Patrice Watson; Mohamed Selima; Richard E Davis; Charles J Filipi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  9     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-31     Completed Date:  2003-06-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  174-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, Creighton University School of Medicine, Omaha, NE 68131, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Esophagogastric Junction / pathology,  physiology*
Female
Gastroesophageal Reflux / diagnosis*
Humans
Hydrogen-Ion Concentration
Male
Manometry
Middle Aged
ROC Curve
Regression Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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