| An analysis of the growth of the retinal cell population in embryonic chicks yielding proliferative ratios, numbers of proliferative and non-proliferative cells and cell-cycle times for successive generations of cell cycles. | |
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MedLine Citation:
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PMID: 7548439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Growth curves of the retinal cell population of embryonic chicks were fitted by a branching-process model of cell population growth, thereby estimating the proliferative ratios and mean cell-cycle times of the generations of cell cycles that underlie retinal growth. The proliferative ratio determines the proportion of cells that divides in the next generation, so the numbers of proliferative and non-proliferative cells in each generation of cell cycles were obtained. The mean cell-cycle times determine the times over which the generations are extant. Assuming growth starts from one cell in generation 0, the proliferative cells reach 3.6 x 10(6) and the non-proliferative cells reach 1.1 x 10(6) by generation 23. The next four generations increase the proliferative cell numbers to 13.9 x 10(6) and produce 20.1 x 10(6) non-proliferative cells. In the next five generations in the end phase of growth, non-proliferative cells are produced in large numbers at an average of 13.9 x 10(6) cells per generation as the retinal lineages are completed. The retinal cell population reaches a maximum estimated here at 98.2 x 10(6) cells. The mean cell-cycle time estimates range between 6.8 and 10.1 h in generations before the end phase of growth and between 10.6 and 17.2 h in generations in the end phase. The retinal cell population growth is limited by the depletion of the proliferative cell population that the production of non-proliferative cells entails. The proliferative ratios and the cell-cycle-time distribution parameters are the likely determinants of retinal growth rates. The results are discussed in relation to other results of spatial and temporal patterns of the cessation of cell cycling in the embryonic chick retina. |
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Authors:
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V B Morris; R Cowan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell proliferation Volume: 28 ISSN: 0960-7722 ISO Abbreviation: Cell Prolif. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-10-24 Completed Date: 1995-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105195 Medline TA: Cell Prolif Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 373-91 Citation Subset: IM |
Affiliation:
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School of Biological Sciences, University of Sydney, NSW, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Count Cell Cycle / physiology Cell Division / genetics Chick Embryo DNA / analysis Data Interpretation, Statistical Growth Inhibitors / pharmacology Periodicity Razoxane / pharmacology Reproducibility of Results Retina / cytology*, embryology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Growth Inhibitors; 21416-87-5/Razoxane; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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