| Clinical/pathological analysis of gallbladder adenomyomatosis; type and pathogenesis. | |
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MedLine Citation:
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PMID: 20698201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: The aim of this study was to analyze the clinical/pathological outcomes of patients that underwent surgery for gallbladder adenomyomatosis, to clarify the characteristics of the type and pathogenesis of adenomyomatosis. METHODOLOGY: From May 1997 to March 2008, 4704 consecutive patients underwent cholecystectomy at Ajou University Medical Center. Among them, 113 (2.4%) patients that were histopathologically diagnosed with adenomyomatosis or adenomatous hyperplasia were selected for this study. The patients were divided into a fundal type group and a segmental/diffuse type group, and the specimens reviewed with Hematoxylin-Eosin (H & E) and immunohistochemical stainings. RESULTS: Sixty-three patients were male and 50 female; the age ranged from 17 to 76 years of age. The fundal type was the most common type. Gallstones were present in 69.9% of the patients. In the analysis of the fundal and segmental/diffuse types, gallstones were present in 23 patients with fundal type and in 53 patients with segmental/diffuse type; this difference was statistically significant (p < 0.05). Review of H & E staining showed that the most common findings were grade 1 (n = 14) in the fundal type and grade 2 (n = 23) in the segmental/diffuse type; there was a significant difference in the inflammatory grade (p < 0.05). Immunohistochemical staining showed expression of vimentin, as a mesenchymal marker in 28.0% of cases (n = 16). CONCLUSIONS: The fundal type differed from the segmental/diffuse type based on the clinical/ pathological features; it had a lower frequency of gallstones and a lower inflammatory grade. In addition, no cancer was identified in the resected gallbladders of patients with adenomyomatosis. The findings suggest that the Rokitansky-Aschoff sinuses (RAS) were associated with acquired motility, based on the expression of vimentin, consistent with an epithelial-mesenchymal transition. |
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Authors:
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Ji Hun Kim; In Ho Jeong; Jae Ho Han; Jang Hee Kim; Jae Chul Hwang; Byung Moo Yoo; Jin Hong Kim; Myung Wook Kim; Wook Hwan Kim |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 57 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2010-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 420-5 Citation Subset: IM |
Affiliation:
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Department of Surgery, School of Medicine, Ajou University, Suwon, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenomyoma
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etiology,
pathology*,
surgery Adolescent Adult Aged Epithelial Cells / pathology Female Gallbladder Neoplasms / etiology, pathology*, surgery Gallstones / etiology Humans Male Mesoderm / pathology Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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