Document Detail


Clinical/pathological analysis of gallbladder adenomyomatosis; type and pathogenesis.
MedLine Citation:
PMID:  20698201     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: The aim of this study was to analyze the clinical/pathological outcomes of patients that underwent surgery for gallbladder adenomyomatosis, to clarify the characteristics of the type and pathogenesis of adenomyomatosis. METHODOLOGY: From May 1997 to March 2008, 4704 consecutive patients underwent cholecystectomy at Ajou University Medical Center. Among them, 113 (2.4%) patients that were histopathologically diagnosed with adenomyomatosis or adenomatous hyperplasia were selected for this study. The patients were divided into a fundal type group and a segmental/diffuse type group, and the specimens reviewed with Hematoxylin-Eosin (H & E) and immunohistochemical stainings. RESULTS: Sixty-three patients were male and 50 female; the age ranged from 17 to 76 years of age. The fundal type was the most common type. Gallstones were present in 69.9% of the patients. In the analysis of the fundal and segmental/diffuse types, gallstones were present in 23 patients with fundal type and in 53 patients with segmental/diffuse type; this difference was statistically significant (p < 0.05). Review of H & E staining showed that the most common findings were grade 1 (n = 14) in the fundal type and grade 2 (n = 23) in the segmental/diffuse type; there was a significant difference in the inflammatory grade (p < 0.05). Immunohistochemical staining showed expression of vimentin, as a mesenchymal marker in 28.0% of cases (n = 16). CONCLUSIONS: The fundal type differed from the segmental/diffuse type based on the clinical/ pathological features; it had a lower frequency of gallstones and a lower inflammatory grade. In addition, no cancer was identified in the resected gallbladders of patients with adenomyomatosis. The findings suggest that the Rokitansky-Aschoff sinuses (RAS) were associated with acquired motility, based on the expression of vimentin, consistent with an epithelial-mesenchymal transition.
Authors:
Ji Hun Kim; In Ho Jeong; Jae Ho Han; Jang Hee Kim; Jae Chul Hwang; Byung Moo Yoo; Jin Hong Kim; Myung Wook Kim; Wook Hwan Kim
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  57     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-08-11     Completed Date:  2010-09-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  420-5     Citation Subset:  IM    
Affiliation:
Department of Surgery, School of Medicine, Ajou University, Suwon, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adenomyoma / etiology,  pathology*,  surgery
Adolescent
Adult
Aged
Epithelial Cells / pathology
Female
Gallbladder Neoplasms / etiology,  pathology*,  surgery
Gallstones / etiology
Humans
Male
Mesoderm / pathology
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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