| An analysis of factors affecting the incidence of inhibitor formation in patients with congenital haemophilia in Japan. | |
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MedLine Citation:
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PMID: 21682824 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Summary. Studies conducted in European and North American countries have demonstrated that various factors including races affect the frequency of inhibitor formation in haemophilia patients. The present study was undertaken to analyse factors affecting the incidence of inhibitor formation in Japanese haemophilia A and B patients. Analytical data were retrospectively collected from haemophilia A and B patients born after 1988, the year when monoclonal antibody-purified factor VIII products were first marketed in Japan. Various data were collected from 184 patients (153 cases of haemophilia A; 31 cases of haemophilia B). The sample size of haemophilia B cases was too small to reveal any significant differences between the inhibitor formation group and the inhibitor-free group in any of background variables. For patients with haemophilia A, on the other hand, univariate analysis identified the severity of haemophilia and a positive family history of inhibitor development as risk factors for the formation of inhibitors. In analyses of the clotting factor products used, the incidence of inhibitor formation did not differ significantly between the group treated with plasma-derived products (29.7%) and the group treated with recombinant products (25.0%). When background variables were compared, age was higher in the group treated with plasma-derived products but none of the other background variables differed between the two groups. These results suggest that in Japanese haemophilia patients, the type of clotting factor preparations used for therapy has not influenced the incidence of inhibitor formation. |
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Authors:
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A Shirahata; K Fukutake; S Higasa; J-I Mimaya; T Oka; M Shima; J Takamatsu; M Taki; M Taneichi; A Yoshioka; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-20 |
Journal Detail:
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Title: Haemophilia : the official journal of the World Federation of Hemophilia Volume: - ISSN: 1365-2516 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9442916 Medline TA: Haemophilia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Paediatrics, University of Occupational and Environmental Health, Kitakyushu, Fukuoka Department of Laboratory Medicine, Tokyo Medical University, Tokyo Division of Haematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo Division of Haematology and Oncology, Shizuoka Children's Hospital, Shizuoka Department of Paediatrics, Sapporo Tokushukai Hospital, Sapporo Department of Paediatrics, Nara Medical University, Kashihara, Nara Department of Transfusion Medicine, Nagoya University Hospital, Nagoya Department of Paediatrics, St Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo Nara Medical University, Kashihara, Nara, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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