Document Detail

An analysis of anemia and pregnancy-related maternal mortality.
MedLine Citation:
PMID:  11160593     Owner:  NLM     Status:  MEDLINE    
The relationship of anemia as a risk factor for maternal mortality was analyzed by using cross-sectional, longitudinal and case-control studies because randomized trials were not available for analysis. The following six methods of estimation of mortality risk were adopted: 1) the correlation of maternal mortality rates with maternal anemia prevalence derived from national statistics; 2) the proportion of maternal deaths attributable to anemia; 3) the proportion of anemic women who die; 4) population-attributable risk of maternal mortality due to anemia; 5) adolescence as a risk factor for anemia-related mortality; and 6) causes of anemia associated with maternal mortality. The average estimates for all-cause anemia attributable mortality (both direct and indirect) were 6.37, 7.26 and 3.0% for Africa, Asia and Latin America, respectively. Case fatality rates, mainly for hospital studies, varied from <1% to >50%. The relative risk of mortality associated with moderate anemia (hemoglobin 40-80 g/L) was 1.35 [95% confidence interval (CI): 0.92-2.00] and for severe anemia (<47 g/L) was 3.51 (95% CI: 2.05-6.00). Population-attributable risk estimates can be defended on the basis of the strong association between severe anemia and maternal mortality but not for mild or moderate anemia. In holoendemic malarious areas with a 5% severe anemia prevalence (hemoglobin <70 g/L), it was estimated that in primigravidae, there would be 9 severe-malaria anemia-related deaths and 41 nonmalarial anemia-related deaths (mostly nutritional) per 100,000 live births. The iron deficiency component of these is unknown.
B J Brabin; M Hakimi; D Pelletier
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  131     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  604S-614S; discussion 614S-615S     Citation Subset:  IM    
Liverpool School of Tropical Medicine, Liverpool, England.
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MeSH Terms
Acute Disease
Africa / epidemiology
Anemia / epidemiology,  mortality*
Anemia, Iron-Deficiency / mortality
Asia / epidemiology
Cause of Death
Chronic Disease
Cross-Sectional Studies
Developing Countries / statistics & numerical data*
Folic Acid Deficiency / mortality
Latin America / epidemiology
Longitudinal Studies
Maternal Mortality
Pregnancy Complications, Hematologic / epidemiology,  mortality*
Pregnancy in Adolescence / statistics & numerical data
Risk Assessment

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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