Document Detail

An analysis of anemia and child mortality.
MedLine Citation:
PMID:  11160595     Owner:  NLM     Status:  MEDLINE    
The relationship of anemia as a risk factor for child mortality was analyzed by using cross-sectional, longitudinal and case-control studies, and randomized trials. Five methods of estimation were adopted: 1) the proportion of child deaths attributable to anemia; 2) the proportion of anemic children who die in hospital studies; 3) the population-attributable risk of child mortality due to anemia; 4) survival analyses of mortality in anemic children; and 5) cause-specific anemia-related child mortality. Most of the data available were hospital based. For children aged 0-5 y the percentage of deaths due to anemia was comparable for reports from highly malarious areas in Africa (Sierra Leone 11.2%, Zaire 12.2%, Kenya 14.3%). Ten values available for hemoglobin values <50 g/L showed a variation in case fatality from 2 to 29.3%. The data suggested little if any dose-response relating increasing hemoglobin level (whether by mean value or selected cut-off values) with decreasing mortality. Although mortality was increased in anemic children with hemoglobin <50 g/L, the evidence for increased risk with less severe anemia was inconclusive. The wide variation for mortality with hemoglobin <50 g/L is related to methodological variation and places severe limits on causal inference; in view of this, it is premature to generate projections on population-attributable risk. A preliminary survival analysis of an infant cohort from Malawi indicated that if the hemoglobin decreases by 10 g/L at age 6 mo, the risk of dying becomes 1.72 times higher. Evidence from a number of studies suggests that mortality due to malarial severe anemia is greater than that due to iron-deficiency anemia. Data are scarce on anemia and child mortality from non-malarious regions. Primary prevention of iron-deficiency anemia and malaria in young children could have substantive effects on reducing child mortality from severe anemia in children living in malarious areas.
B J Brabin; Z Premji; F Verhoeff
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  131     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  636S-645S; discussion 646S-648S     Citation Subset:  IM    
Liverpool School of Tropical Medicine, Liverpool, England.
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MeSH Terms
Age Distribution
Age Factors
Anemia / blood,  mortality*,  therapy
Anemia, Iron-Deficiency / blood,  mortality,  therapy
Blood Transfusion / mortality
Case-Control Studies
Child, Preschool
Cross-Sectional Studies
Developing Countries / statistics & numerical data
Infant, Newborn
Longitudinal Studies
Malaria / complications,  mortality
Randomized Controlled Trials as Topic
Sex Distribution
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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