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An analysis of 8 cases of factor X deficiency.
MedLine Citation:
PMID:  23100936     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Factor X deficiency is a rare coagulation defect. There are occasional reports of factor X deficiency from India. Difficulty in accurate diagnosis and non-availability of ideal treatment is discussed.
METHODS: Eight cases of factor X deficiency, diagnosed from 1992 to 2007 are reported here
RESULTS: Seven were male while one was female. Seven patients were symptomatic from early childhood. One patient became symptomatic from 18 years of age. Factor X assay was done in 4 patients, 3 had severe deficiency and one had mild deficiency. One patient had associated factor IX deficiency. Three patients had repeated bleeding episodes requiring multiple transfusions. Two patients had intracranial bleed and one had umbilical cord bleeding at birth. There was no mortality. No patient received prophylactic transfusion.
CONCLUSIONS: Factor X deficiency is a rare coagulation defect. Hereditary deficiency should be distinguished from acquired deficiency. CNS, joints and skin are the common sites of bleeding.
Authors:
Nilam M Shah; Ashwin P Patel
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Publication Detail:
Type:  Journal Article     Date:  2008-05-01
Journal Detail:
Title:  Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion     Volume:  24     ISSN:  0971-4502     ISO Abbreviation:  Indian J Hematol Blood Transfus     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2012-10-26     Completed Date:  2012-10-29     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  9425818     Medline TA:  Indian J Hematol Blood Transfus     Country:  India    
Other Details:
Languages:  eng     Pagination:  23-5     Citation Subset:  -    
Affiliation:
Saumrut laboratory, 402, Narayan complex, Near Navrangpura bus stand, Ahmedabad, 380 009 India.
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