| An analgesic model for assessment of acute pain response in osteoarthritis of the knee. | |
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MedLine Citation:
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PMID: 16784879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Osteoarthritis (OA) is frequently treated only during periods of flare, in which rapid onset of analgesia is the outcome target. OBJECTIVE: To assess an acute pain model of knee OA in flare. METHODS: In a multicenter, randomized, double-blind, controlled study, 530 patients aged >or=50 years received valdecoxib 10 mg qd (n=212), rofecoxib 2 5 mg qd (n=208), or placebo (n=110). Pain intensity (PI) was measured on a visual analog scale (VAS) at baseline after a 10-min walk. Patients took their first dose of study medication, rested for 20 min, then measured their PI VAS at 0.5, 1, 1.5, 2, 3, 4, 5, and 6h, each time following a 10-min walk. RESULTS: PI VAS differences (PID) were significantly greater vs placebo both with valdecoxib and rofecoxib (P<0.05) beginning as early as 3h (intent-to-treat population). The percentage of patients with analgesia onset from 4h was significantly higher with both valdecoxib (55%) and rofecoxib (56%) relative to placebo (40%). Median time to first onset of analgesic was shorter with both valdecoxib and rofecoxib compared with placebo (P=0.104 vs valdecoxib; P=0.036 vs rofecoxib). CONCLUSIONS: This acute pain model of knee OA flare detected significant pain relief with agents known to relieve pain in OA and placebo within hours after the first treatment dose, allowing assessment of pain relief within hours rather than days or weeks when evaluating analgesic efficacy in OA. This model is undergoing further study to determine optimal walk times, distances, and rates to maximize its sensitivity. |
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Authors:
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R W Moskowitz; A Sunshine; M Hooper; N Z Olson; G D Cawkwell |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-06-19 |
Journal Detail:
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Title: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society Volume: 14 ISSN: 1063-4584 ISO Abbreviation: Osteoarthr. Cartil. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-10 Completed Date: 2007-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305697 Medline TA: Osteoarthritis Cartilage Country: England |
Other Details:
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Languages: eng Pagination: 1111-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals, Cleveland, OH 44122, USA. roland.moskowitz@uhhs.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Aged, 80 and over Cyclooxygenase 2 Inhibitors / adverse effects, therapeutic use Cyclooxygenase Inhibitors / adverse effects, therapeutic use* Double-Blind Method Female Humans Isoxazoles / adverse effects, therapeutic use Lactones / adverse effects, therapeutic use Male Middle Aged Models, Biological Osteoarthritis, Knee / drug therapy*, physiopathology Pain Measurement / methods* Severity of Illness Index Sulfonamides / adverse effects, therapeutic use Sulfones / adverse effects, therapeutic use Time Factors Treatment Outcome Walking / physiology |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase 2 Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Isoxazoles; 0/Lactones; 0/Sulfonamides; 0/Sulfones; 0/rofecoxib; 0/valdecoxib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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