| The analgesic efficacy of continuous wound instillation with ropivacaine after open hepatic surgery. | |
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MedLine Citation:
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PMID: 20958277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The analgesic efficacy of continuous local anaesthetic wound instillation after open hepatic surgery was evaluated. Forty-eight patients scheduled for elective liver surgery were assigned to receive either ropivacaine 0.25% or saline infusion at 4 ml.h(-1) for 68 h via two multi-orifice indwelling catheters placed within the musculo-fascial layer before skin closure; plasma ropivacaine concentrations were measured during the infusion. Supplemental analgesia was provided by intravenous patient-controlled analgesia morphine. Patients in the ropivacaine group had decreased mean (SD) total morphine consumption (58 (30) mg vs 86 (44) mg, p = 0.01) and less pain at rest as well as after spirometry at 4, 12, 24, 48 and 72 h postoperatively (p < 0.01). Forced vital capacity was reduced postoperatively in both groups, but the reduction was greater in the saline group at 12 and 24 h (p = 0.03). The mean plasma concentration of ropivacaine increased to 2.05 (0.78) μg.ml(-1) at the point when the infusion was terminated. |
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Authors:
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S K Chan; P B Lai; P T Li; J Wong; M K Karmakar; K F Lee; T Gin |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-10-19 |
Journal Detail:
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Title: Anaesthesia Volume: 65 ISSN: 1365-2044 ISO Abbreviation: Anaesthesia Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-24 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 1180-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. simonkcchan@cuhk.edu.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Wall Adolescent Adult Aged Amides / administration & dosage*, blood Analgesics, Opioid / administration & dosage Anesthetics, Local / administration & dosage*, blood Female Hepatectomy / methods* Humans Infusions, Intralesional Liver Neoplasms / surgery Male Middle Aged Morphine / administration & dosage Pain Measurement / methods Pain, Postoperative / prevention & control* Postoperative Care / methods Vital Capacity / drug effects Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Analgesics, Opioid; 0/Anesthetics, Local; 57-27-2/Morphine; 84057-95-4/ropivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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