Document Detail


The analgesic efficacy of continuous wound instillation with ropivacaine after open hepatic surgery.
MedLine Citation:
PMID:  20958277     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The analgesic efficacy of continuous local anaesthetic wound instillation after open hepatic surgery was evaluated. Forty-eight patients scheduled for elective liver surgery were assigned to receive either ropivacaine 0.25% or saline infusion at 4 ml.h(-1) for 68 h via two multi-orifice indwelling catheters placed within the musculo-fascial layer before skin closure; plasma ropivacaine concentrations were measured during the infusion. Supplemental analgesia was provided by intravenous patient-controlled analgesia morphine. Patients in the ropivacaine group had decreased mean (SD) total morphine consumption (58 (30) mg vs 86 (44) mg, p = 0.01) and less pain at rest as well as after spirometry at 4, 12, 24, 48 and 72 h postoperatively (p < 0.01). Forced vital capacity was reduced postoperatively in both groups, but the reduction was greater in the saline group at 12 and 24 h (p = 0.03). The mean plasma concentration of ropivacaine increased to 2.05 (0.78) μg.ml(-1) at the point when the infusion was terminated.
Authors:
S K Chan; P B Lai; P T Li; J Wong; M K Karmakar; K F Lee; T Gin
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-10-19
Journal Detail:
Title:  Anaesthesia     Volume:  65     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-24     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1180-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. simonkcchan@cuhk.edu.hk
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MeSH Terms
Descriptor/Qualifier:
Abdominal Wall
Adolescent
Adult
Aged
Amides / administration & dosage*,  blood
Analgesics, Opioid / administration & dosage
Anesthetics, Local / administration & dosage*,  blood
Female
Hepatectomy / methods*
Humans
Infusions, Intralesional
Liver Neoplasms / surgery
Male
Middle Aged
Morphine / administration & dosage
Pain Measurement / methods
Pain, Postoperative / prevention & control*
Postoperative Care / methods
Vital Capacity / drug effects
Young Adult
Chemical
Reg. No./Substance:
0/Amides; 0/Analgesics, Opioid; 0/Anesthetics, Local; 57-27-2/Morphine; 84057-95-4/ropivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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