Document Detail

The analgesic effect of intrathecal dexmedetomidine or clonidine, with bupivacaine, in trauma patients undergoing lower limb surgery: a randomised, double-blind study.
MedLine Citation:
PMID:  23362890     Owner:  NLM     Status:  MEDLINE    
This randomised, double-blind study was designed to compare the duration of analgesia and adverse effects following intrathecal administration of dexmedetomidine or clonidine, both with bupivacaine, in trauma patients. Ninety adult trauma patients of American Society of Anesthesiologists physical status I-II, scheduled for lower limb surgery under subarachnoid block, were randomly allocated to one of three groups. All groups received hyperbaric bupivacaine 0.5% 3 ml, to which was added saline 0.5 ml (Group B): clonidine 50 µg (Group C) or dexmedetomidine 5 µg (Group D). The onset and duration of sensory and motor blockade, severity of postoperative pain, time to first rescue analgesia and total analgesic requirement for 24 hours were noted. There was no significant difference in the onset time of the block but the duration of sensory and motor blockade was prolonged in Groups C and D, compared with Group B. The time to analgesia was significantly prolonged in Group D (824±244 minutes) compared with Group C (678±178 minutes; P=0.01), the latter being longer than Group B (406±119 minutes; P=0.0001). Postoperative pain scores were lower in Groups C and D compared with group b. The requirement for rescue analgesia during the first 24 postoperative hours was significantly less in Groups C and D as compared to Group B (P=0.0001), but comparable between Groups C and D (P=0.203). In conclusion, dexmedetomidine 5 µg added to intrathecal bupivacaine 15 mg produces longer postoperative analgesia than clonidine 50 µg among trauma patients undergoing lower limb surgery.
S L Solanki; N Bharti; Y K Batra; A Jain; P Kumar; S A Nikhar
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  41     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-03-01     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  IM    
Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Analgesics / administration & dosage,  pharmacology
Analgesics, Non-Narcotic / administration & dosage,  pharmacology
Anesthetics, Local / administration & dosage,  pharmacology
Bupivacaine / administration & dosage,  pharmacology*
Clonidine / administration & dosage,  pharmacology*
Dexmedetomidine / administration & dosage,  pharmacology*
Double-Blind Method
Drug Therapy, Combination
Injections, Spinal
Lower Extremity / injuries,  surgery
Middle Aged
Nerve Block / methods
Pain, Postoperative / prevention & control*
Severity of Illness Index
Time Factors
Wounds and Injuries / surgery
Young Adult
Reg. No./Substance:
0/Analgesics; 0/Analgesics, Non-Narcotic; 0/Anesthetics, Local; 113775-47-6/Dexmedetomidine; 2180-92-9/Bupivacaine; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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