Document Detail

The analgesic effect of EMLA cream on facial skin. Quantitative evaluation using argon laser stimulation.
MedLine Citation:
PMID:  1357887     Owner:  NLM     Status:  MEDLINE    
The hypoalgesic effect of EMLA cream (Eutectic Mixture of Local Anesthetics) applied for 5, 15, and 30 min on facial skin was evaluated. Hypoalgesia was assessed by changes in pain thresholds to brief argon laser stimuli 0, 2, 5, 10, 15, 20, 25, 30, 45, and 60 min after removal of EMLA cream. The local cutaneous vascular changes induced by EMLA cream was evaluated by Erythema Index determined by reflectance spectroscopy and by laser Doppler blood flowmetry. A large inter-individual variability in analgesic efficacy was observed. The volunteers could be divided into two groups, one group of 6 persons where EMLA induced analgesia or considerable hypoalgesia, and one group of 4 persons where EMLA had no or only slight hypoalgesic effect. This great variability should be considered when EMLA cream is used for facial application in the clinic. Differences in local blood flow probably contribute to the variability. Application of EMLA cream for 5 and 15 min did not change erythema of the skin, while 30 min of application caused minor blanching.
J C Nielsen; L Arendt-Nielsen; P Bjerring; P Svensson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  72     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-11-23     Completed Date:  1992-11-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  281-4     Citation Subset:  IM    
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
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MeSH Terms
Anesthetics, Local / pharmacology*
Drug Combinations
Evaluation Studies as Topic
Lasers / diagnostic use
Lidocaine / pharmacology*
Middle Aged
Pain Measurement / drug effects*
Prilocaine / pharmacology*
Skin / drug effects*,  physiopathology
Reg. No./Substance:
0/Anesthetics, Local; 0/Drug Combinations; 0/EMLA; 137-58-6/Lidocaine; 721-50-6/Prilocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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