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Ferritin/alanine aminotransferase ratio as a possible marker for predicting the prognosis of acute liver injury.
MedLine Citation:
PMID:  21501222     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background/Aims: Serum levels of ferritin and heme oxygenase (HO)-1 are both markers of macrophage activation. We evaluated simple markers for predicting the prognosis of severe acute liver injury in which macrophage activation plays an important role. Methods: Subjects comprised 114 patients with acute liver injury, admitted to the liver unit of Nagasaki Medical Center between January 2001 and September 2010. Subjects included 11 patients with fulminant hepatic failure (FHF), 82 patients with ordinary acute hepatitis (AH), and 21 patients with severe-form AH (AHS). We determined serum levels of ferritin, HO-1 and other biochemical makers, and analyzed relationships between clinical outcomes of patients and each of these parameters alone and in combination. Results: Median serum ferritin levels were significantly higher in FHF (25,900 ng/ml) and AHS (3,060 ng/ml) than in AH (700 ng/ml; p < 0.01 each). Median HO-1 levels were also significantly higher in FHF (123 ng/ml) and AHS (51 ng/ml) than in AH (19 ng/ml; p < 0.01 each). Similarly, median ferritin/alanine aminotransferase (F/A) ratio was significantly higher in FHF (6.7) than in AHS (1.6, p < 0.05) or AH (0.5, p < 0.01). Among the 11 FHF patients, 3 recovered, 7 died and 1 underwent liver transplantation. The ability of F/A ratio to distinguish non-survivors from survivors was analyzed using receiver operating characteristics curves. A cut-off level of 3.12 provided high sensitivity (87.5%) and specificity (81.2%). Conclusion: These results suggest that F/A ratio offer a quick and simple marker for predicting the prognosis of acute liver injury.
Authors:
Eisuke Ozawa; Seigo Abiru; Shinya Nagaoka; Koji Yano; Atsumasa Komori; Kiyoshi Migita; Hiroshi Yatsuhashi; Naota Taura; Tatsuki Ichikawa; Hiromi Ishibashi; Kazuhiko Nakao
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-18
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki 856-8562, Japan Department Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto 1-7-1, Nagasaki 852-8501 Japan.
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