Document Detail


The amino-acid sequence of the trypsin-released inhibitor from sheep inter-alpha-trypsin inhibitor.
MedLine Citation:
PMID:  2441725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The amino-acid sequence of the inhibitory part of the sheep serum inter-alpha-trypsin inhibitor (ITI) was determined. The inhibitor is composed of two covalently linked Kunitz-type domains. The reactive site of the C-terminal antitryptic domain contains arginine in position 71 (P1) and glycine in position 73 (P'2), whereas ITI derived inhibitors hitherto investigated contain phenylalanine in these positions. The reactive site of the N-terminal elastase inhibiting domain contains leucine in position 15 (P1) and methionine in position 17 (P'2), as in ITI-derived inhibitors of pig and horse.
Authors:
G Rasp; K Hochstrasser; E Wachter; P W Reisinger
Related Documents :
6205695 - The two alpha 2-macroglobulin-bound trypsin molecules have different affinities for the...
6885745 - A possible evolutionary relationship between plant trypsin inhibitor, alpha-amylase inh...
2441725 - The amino-acid sequence of the trypsin-released inhibitor from sheep inter-alpha-trypsi...
9748655 - Phosphorylation of mycobacterium leprae heat-shock 70 protein at threonine 175 alters i...
11114505 - Ab(5) toxins: structures and inhibitor design.
7903455 - Eukaryotic cytosolic chaperonin contains t-complex polypeptide 1 and seven related subu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological chemistry Hoppe-Seyler     Volume:  368     ISSN:  0177-3593     ISO Abbreviation:  Biol. Chem. Hoppe-Seyler     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-10-06     Completed Date:  1987-10-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8503054     Medline TA:  Biol Chem Hoppe Seyler     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  727-31     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alpha-Globulins / analysis*
Amino Acid Sequence
Animals
Hydrolysis
Peptides / analysis
Sheep
Species Specificity
Trypsin
Chemical
Reg. No./Substance:
0/Alpha-Globulins; 0/Peptides; 39346-44-6/inter-alpha-inhibitor; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Horse alpha 2-macroglobulin. Circular dichroism studies of conformational changes upon reaction with...
Next Document:  Toluidine blue staining of the esophagus. A useful adjunct in the panendoscopic evaluation of patien...