Document Detail

The amino-acid sequence of the trypsin-released inhibitor from sheep inter-alpha-trypsin inhibitor.
MedLine Citation:
PMID:  2441725     Owner:  NLM     Status:  MEDLINE    
The amino-acid sequence of the inhibitory part of the sheep serum inter-alpha-trypsin inhibitor (ITI) was determined. The inhibitor is composed of two covalently linked Kunitz-type domains. The reactive site of the C-terminal antitryptic domain contains arginine in position 71 (P1) and glycine in position 73 (P'2), whereas ITI derived inhibitors hitherto investigated contain phenylalanine in these positions. The reactive site of the N-terminal elastase inhibiting domain contains leucine in position 15 (P1) and methionine in position 17 (P'2), as in ITI-derived inhibitors of pig and horse.
G Rasp; K Hochstrasser; E Wachter; P W Reisinger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological chemistry Hoppe-Seyler     Volume:  368     ISSN:  0177-3593     ISO Abbreviation:  Biol. Chem. Hoppe-Seyler     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-10-06     Completed Date:  1987-10-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8503054     Medline TA:  Biol Chem Hoppe Seyler     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  727-31     Citation Subset:  IM    
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MeSH Terms
Alpha-Globulins / analysis*
Amino Acid Sequence
Peptides / analysis
Species Specificity
Reg. No./Substance:
0/Alpha-Globulins; 0/Peptides; 39346-44-6/inter-alpha-inhibitor; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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