Document Detail

An amino acid-modified and non-HEMA containing glass-ionomer cement.
MedLine Citation:
PMID:  14738846     Owner:  NLM     Status:  MEDLINE    
It is known that unreacted 2-hydroxyethyl methacrylate (HEMA) in current resin modified glass ionomer cements (RMGICs) shows potential cytotoxicity to pulp and surrounding tissues. Elimination of HEMA could make RMGICs more attractive for dental applications. In this research, novel six acrylate and methacrylate derivatives of amino acids were synthesized, characterized and used for replace HEMA in RMGICs. The experimental RMGICs were formulated with vinyl-containing polymer, amino acid derivative, water, and commercial Fuji II LC glass. Among all the derivatives, methacryloyl beta-alanine (MBA) was selected for further formulations due to its relatively low solution viscosity and high CS. Effects of polymer content and powder/liquid, P/L, ratio were significant. The formulation with liquid composition of 50/25/25 (polymer/MBA/water) and P/L ratio of 2.7/1 was found the optimal. It appears that this novel non-HEMA-containing RMGIC system based on amino acid derivatives will be a better dental restorative because it demonstrated improved mechanical strengths and may eliminate potential cytotoxicity in current RMGICs caused by leached HEMA. The optimal MBA-modified GIC were 20% higher in CS, 70% higher in DTS and 93% higher in FS, compared to Fuji II LC.
Dong Xie; Il-Doo Chung; Wei Wu; Jack Lemons; Aaron Puckett; Jimmy Mays
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Biomaterials     Volume:  25     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-01-23     Completed Date:  2004-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  1825-30     Citation Subset:  IM    
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
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MeSH Terms
Acrylates / chemistry*
Amino Acids / chemistry*
Biocompatible Materials / chemical synthesis,  chemistry*
Compressive Strength
Glass Ionomer Cements / chemical synthesis,  chemistry*
Materials Testing
Methacrylates / chemistry
Resin Cements / chemical synthesis,  chemistry*
Reg. No./Substance:
0/Acrylates; 0/Amino Acids; 0/Biocompatible Materials; 0/Glass Ionomer Cements; 0/Methacrylates; 0/Resin Cements; 868-77-9/hydroxyethyl methacrylate

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