Document Detail


Is aluminum related bone disease common in hemodialysis units using aluminum based phosphate binders?
MedLine Citation:
PMID:  18583839     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The extent of aluminum related bone disease was evaluated in 41 patients on regular maintenance hemodialysis in two dialysis centers in Riyadh, Saudi Arabia. There were 22 males and 19 females aged 20 to 70 years (mean 35.5+11.2 years). Thirty eight of the patients were on aluminum based oral phosphate binders. Investigations performed included serum calcium, magnesium, aluminum and parathormone and radiological investigations including skeletal survey and dual photon absorptiometry. All the patients underwent bone biopsy and the biopsy material was subjected to morphometric studies, including staining for aluminum deposits. The patients were divided into two groups: group 1, (16 patients, 39%) with negative aluminum staining in the bone biopsy tissue, and group 2, (25 patients, 61%) with positive aluminum staining. Bone pain and its distribution as well as fractures were similarly prevalent in both groups. The levels of aluminum in the blood was significantly higher in group 2 (32.9 + 20.2 vs 17.9 + 11.2 ug/L P< 0.05), though it was lower than the lowest accepted toxic level (40 ig/L). There was no significant difference between the two groups in the biochemical or hormonal data, frequency of abnormal radiological signs and pattern of bone histology. Our study indicates that increased aluminum deposition in the bone is prevalent in patients on maintenance hemodialysis using aluminum based phosphate binders, but adynamic bone disease is not prevalent. Further studies may be needed on a larger scale to assess the magnitude of the problem.
Authors:
M Z Souqiyyeh; S O Huraib; S Aswad; F A Shaheen; A R Al-Swailem
Related Documents :
21431299 - Diagnostic accuracy of 64-slice computed tomography coronary angiography in a large pop...
7582699 - Aetiology and presenting symptoms in male osteoporosis.
8600259 - Prevalence of bone marrow signal abnormalities observed in the temporomandibular joint ...
9412619 - Long-term oral anticoagulation reduces bone mass in patients with previous hemispheric ...
24831229 - Fecal lactoferrin and intestinal permeability are effective non-invasive markers in the...
7296969 - Changes in bone mineral content evaluated by photon absorptiometry before the start of ...
6369509 - Small-bowel bacterial overgrowth in the postgastrectomy syndrome.
22216049 - Electroencephalographic abnormalities in clozapine-treated patients: a cross-sectional ...
9677719 - Persistent diffuse peritonitis in children.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia     Volume:  6     ISSN:  1319-2442     ISO Abbreviation:  Saudi J Kidney Dis Transpl     Publication Date:    1995 January-March
Date Detail:
Created Date:  2008-06-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9436968     Medline TA:  Saudi J Kidney Dis Transpl     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  22-7     Citation Subset:  -    
Affiliation:
Saudi Center for Organ Transplantation, Riyadh, Saudi Arabia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Diagnosis of Acute Renal Allograft Rejection Using T-lymphocyte Subsets in the Peripheral Blood:...
Next Document:  Autosomal dominant polycystic kidney disease: observations from a university hospital in saudi arabi...