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An aluminum marker for the differentiation and separation of virulent and attenuated polioviruses.
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MedLine Citation:
PMID:  14004705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new character, the A marker, for polioviruses is described. In the presence of Al(+++) (1 to 100 mM) attenuated, but not virulent, strains of type 1 and type 2 polioviruses are stabilized so that they resist thermal inactivation at 50 degrees C. Differences between the attenuated and virulent type 3 strains studied were of the opposite character and less marked. By the use of optimal concentrations of Al(+++) (12 mM for type 1 and 1 mM for type 2) attenuated strains can be separated from mixtures containing virulent type 1 or 2 strains. The A marker was found to be correlated with the d but not the rct/40 or T marker. The A marker has been used for following genetic changes of vaccine strains after their multiplication in man.
Authors:
C WALLIS; J L MELNICK; G D FERRY; I L WIMBERLY
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  115     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1962 Apr 
Date Detail:
Created Date:  1962-12-01     Completed Date:  1998-11-01     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  763-75     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Poliovirus*
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1962, by The Rockefeller Institute
Received Day: 1 Month: 1 Year: 1962
Print publication date: Day: 31 Month: 3 Year: 1962
Volume: 115 Issue: 4
First Page: 763 Last Page: 775
ID: 2137513
PubMed Id: 14004705

AN ALUMINUM MARKER FOR THE DIFFERENTIATION AND SEPARATION OF VIRULENT AND ATTENUATED POLIOVIRUSES
Craig Wallis
Joseph L. Melnick
George D. Ferry
Ira L. Wimberly
From the Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas


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