Document Detail

An alternative treatment option in tubal ectopic pregnancies with fetal heartbeat: aspiration of the embryo followed by single-dose methotrexate administration.
MedLine Citation:
PMID:  21601198     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To present 13 cases of unruptured tubal ectopic pregnancies successfully treated with ultrasound-guided aspiration and local and systemic methotrexate (MTX) administration.
DESIGN: Case series.
SETTING: University hospital.
PATIENT(S): Thirteen women with an unruptured tubal ectopic pregnancy.
INTERVENTION(S): Transvaginal ultrasound-guided aspiration of the tubal ectopic pregnancy followed by MTX administration into the gestational sac (half of the calculated total dose of 25 mg/m(2)) and intramuscular injection (the remaining half of the calculated total dose of 25 mg/m(2)).
MAIN OUTCOME MEASURE(S): Recovery of the patients, successful conservative treatment of the tubal ectopic pregnancies with preservation of the fallopian tubes.
RESULT(S): Twelve (92%) of 13 women were successfully aborted, without need for salpingectomy or salpingostomy.
CONCLUSION(S): Transvaginal ultrasound-guided aspiration of fetus followed by local and systemic methotrexate administration can be safely used to treat unruptured tubal ectopic pregnancies.
Ismail Cepni; Onur Güralp; Pelin Ocal; Ramin Salahov; Hazel Gurleyen; Mehmet Idil
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-05-20
Journal Detail:
Title:  Fertility and sterility     Volume:  96     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-04     Completed Date:  2011-08-29     Revised Date:  2012-01-10    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Obstetrics and Gynecology, Division of Reproductive Endocrinology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Drug Administration Schedule
Heart Rate, Fetal* / physiology
Methotrexate / administration & dosage*
Pregnancy, Ectopic / drug therapy,  surgery,  ultrasonography
Pregnancy, Tubal / drug therapy*,  surgery,  ultrasonography*
Retrospective Studies
Suction / methods
Treatment Outcome
Ultrasonography, Interventional / methods
Ultrasonography, Prenatal / methods
Young Adult
Reg. No./Substance:
Comment In:
Fertil Steril. 2011 Dec;96(6):e163; author reply e164   [PMID:  21982287 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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