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An alternative treatment in hypertriglyceridemia-induced acute pancreatitis in pregnancy: Plasmapheresis.
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PMID:  22557756     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Hormonal influences during pregnancy can compromise otherwise controlled lipid levels in women with familial hypertriglyceridemia and predispose to pancreatitis leading to increased morbidity in both mother and fetus. Both cholesterol and triglyceride levels in serum increase progressively during pregnancy. The mainstay of treatment includes dietary restriction of fatty meal and lipid-lowering medications. Experiences with plasmapheresis are limited. We report two cases of hypertriglyceridemia-induced acute pancreatitis during pregnancy, which were successfully treated by plasmapheresis.
Dilek Altun; Gulay Eren; Zafer Cukurova; Oya Hergünsel; Levent Yasar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of anaesthesiology, clinical pharmacology     Volume:  28     ISSN:  2231-2730     ISO Abbreviation:  J Anaesthesiol Clin Pharmacol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-04     Completed Date:  2012-10-02     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  9516972     Medline TA:  J Anaesthesiol Clin Pharmacol     Country:  India    
Other Details:
Languages:  eng     Pagination:  252-4     Citation Subset:  -    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Anaesthesiol Clin Pharmacol
Journal ID (iso-abbrev): J Anaesthesiol Clin Pharmacol
Journal ID (publisher-id): JOACP
ISSN: 0970-9185
ISSN: 2231-2730
Publisher: Medknow Publications & Media Pvt Ltd, India
Article Information
Copyright: © Journal of Anaesthesiology Clinical Pharmacology
Print publication date: Season: Apr-Jun Year: 2012
Volume: 28 Issue: 2
First Page: 252 Last Page: 254
ID: 3339738
PubMed Id: 22557756
Publisher Id: JOACP-28-252
DOI: 10.4103/0970-9185.94913

An alternative treatment in hypertriglyceridemia-induced acute pancreatitis in pregnancy: Plasmapheresis
Dilek Altunaff1
Gulay Erenaff1
Zafer Cukurovaaff1
Oya Hergünselaff1
Levent Yasar1
Department of Anesthesiology and Intensive Care, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
1Department of Obstetrics and Gynecology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
Correspondence: Address for correspondence: Dr. Gulay Eren, Denizatikent A2 Blok, No:57, Zeytinburnu, Istanbul, Turkey. E-mail:


Hypertriglyceridemia is a known cause of acute pancreatitis (AP).[1] Hypertriglyceridemia may be primary, such as in chylomicronemia syndrome, or secondary to alcohol abuse, diabetes mellitus, estrogen use, as well as pregnancy. It is one of the important causes of acute nonbiliary pancreatitis in pregnancy.[2, 3] AP rarely complicates pregnancy. It is estimated to occur in 1 in 1,000 to 1 in 12,000 pregnancies.[4] Older reviews of AP in pregnancy reported maternal and fetal mortality rates as high as 20% and 50%, respectively.[4, 5] Contemporary reports documented a much improved outcome of AP in pregnancy, when the management of AP secondary to gallstones has undergone substantial changes like endoscopic retrograde cholangiopancreatography (ERCP) and laparoscopic cholecystectomy.[6, 7] A single centre cohort study over 10 years has described no maternal death with fetal loss of 4.7% in 34 parturients who had AP.[7]

Cholesterol and triglyceride (TG) plasma levels physiologically increase during pregnancy. AP is the main consequence of hyperlipidemia and it can occur either during pregnancy, in the third trimester, or in the puerperium. AP might be seen in cases with familial hypertriglyceridemia at pregnancy and cases resistant to medical therapy can be treated with plasmapheresis successfully.[8, 9]

We report (with the informed consent of the patients) the successful treatment of plasmapheresis in two pregnant women that had familial hypertriglyceridemia causing AP during pregnancy.

Case Reports
Case 1

A 27-year-old primipara woman, in the 5th week of gestation, was referred to the obstetrical emergency for an acute abdominal pain with vomiting and fever. The epigastric pain was continuous and radiating to the back, with aggravation in supine position and relief on crouching forward. Her sister had a history of gestational AP due to familial hypertriglyceridemia. Her physical examination was unremarkable. The TG and amylase levels were high and there was leucocytosis [Table 1]. Other biochemical parameters and the coagulation tests were normal. Magnetic resonance imaging (MRI) findings were consistent with AP. Despite medical therapy as there was no reduction in TG and on the sixth day of admission to the hospital, she was shifted to intensive care unit (ICU) for plasmapheresis. We used fresh frozen plasma (FFP) for therapeutic plasma exchange with a volume of 40 ml per kg body weight (BW) along with heparin infusion 10 U/kg/h for anticoagulation. The plasmapheresis treatment was ceased as there was a significant drop of TG after three sessions [Figure 1]. In the second week, because of the fetal loss, pregnancy was terminated. In 8 days time, with the levels of TG 278 mg/dL and cholesterol 181 mg/dL, she was discharged from the hospital. After discharge, she regularly visited the outpatient department without any complications.

Case 2

A 24-year-old primigravida patient, in the 27th week of gestation, was admitted to the obstetrics and gynecology department with acute onset of nausea, vomiting, and aggravated epigastric pain. Laboratory findings, except the lipid profile, were normal [Table 1]. She was admitted to the ICU for treatment of pancreatitis. She had familial history of hypertriglyceridemia. MRI findings were consistent with AP. As there was no reduction in TG levels despite medical therapy, the treating multidisciplinary team decided to initiate plasmapheresis and eight sessions with 3 days intervals were planned. After completion of plasmapheresis sessions, the patient was sent to the ward for the continuation of supportive treatment. Within 10 days, despite to the dietary restriction of fat and administration of lipid-lowering agents, the level of TGs again increased (TG 2483 mg/dL and cholesterol 351 mg/dL) and six more sessions of plasmapheresis were planned. In all the sessions, FFP (40 ml/kg BW) and heparin (10 U/kg/h) were used. The lipid values slowly returned toward normal during the following days [Figure 2]. On the 21st day of her second admission, the patient was sent back to the obstetrics ward. She was kept on lipid-lowering dietary and drug therapy until the 34th week of gestation. Cesarean delivery was performed under spinal anesthesia in the 34th week, and the patient delivered a healthy 3100 g female infant. Her lipids became normal thereafter and she was followed up in the outpatient clinic.


Hypertriglyceridemia-induced pancreatitis is a serious complication of familial dyslipidemias. Hormonal influences during pregnancy can compromise otherwise controlled lipid levels in women with familial hypertriglyceridemia and predispose to pancreatitis.[10] Plasma TG increase two-fold to four-fold in pregnancy, principally in the third trimester, because of increased TG-rich lipoprotein production and decreased lipoprotein lipase activity.[11] In women with abnormal lipoprotein metabolism, this can lead to severe hypertriglyceridemia, precipitating pancreatitis.[12] General and specific therapy is available to reduce TG levels during the acute phase of pancreatitis, which may improve the outcome. Nutrition and pharmacologic therapy may be essential in preventing further attacks. Plasmapheresis is an alternative, safe, and successful treatment for the cases resistant to the medical treatment. We successfully used plasmapheresis to manage hypertriglyceridemia-induced pancreatitis during pregnancy.

Hypertriglyceridemia-induced pancreatitis during pregnancy has been reported previously.[1315] The clinical course and treatment of pancreatitis due to hypertriglyceridemia are similar to those of pancreatitis of other causes. Family history of lipid abnormalities should be elicited, and an attempt to identify secondary causes made. A serum TG level >1,000 mg/dL is an identifiable risk factor. Reduction of TG levels to well below 1,000 mg/dL effectively prevents further episodes of pancreatitis.[16, 17] The mainstay of treatment for the hypertriglyceridemia associated with pancreatitis includes dietary restriction of fat and administration of lipid-lowering agents.[1, 2] To prevent AP, hospitalization for intravenous fluid therapy and plasma exchange may be required. Plasmapheresis and extracorporeal lipid elimination are therapeutic alternatives.[3, 8] Plasma exchange can dramatically reduce excessive lipid levels,[18, 19] as was seen in our two cases. Our second patient presented with triglyceridemia-induced pancreatitis in the 27th week of pregnancy. There was no previous history of lipid abnormality, diabetes mellitus, alcohol ingestion, or any other precipitating factor apart from family history. Plasma TG level was 2699 mg/dL at admission.

Pancreatitis in pregnancy is associated with a high maternal death and fetal loss rate. These rates are declining with earlier diagnosis of the disease.[20] Treatment in early phase is important both for the fetus and the mother's health. The commonest reasons for maternal and fetal mortality are AP itself and, very rarely, AP is associated with preeclampsia–eclampsia or HELLP syndrome.[15, 21] In our first case, pregnancy had to be terminated, but in the second case the patient delivered a healthy infant. The incidence of preterm delivery and perinatal death in these patients is higher than that in the general obstetric population.[2224] Ramin et al. demonstrated that, of pregnancies complicated with pancreatitis, 19% had AP in the first trimester, 26% in the second, 53% at more than 28 weeks gestation, and 2% postpartum.[4] One of our patients was at 5th gestational week and the other was at 27th gestational week.

The incidence of pancreatitis during pregnancy is low, but related morbidity and mortality are high. Early and prompt treatment is the key factor to successful outcome. Plasmapheresis is an alternative and safe treatment for the cases resistant to the medical therapy. The early application of plasmapheresis in parturients with hypertriglyceridemia-induced AP may improve the clinical course.


Source of Support: Nil

Conflict of Interest: None declared.

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[Figure ID: F1]
Figure 1 

The time-course of plasmapheresis therapy of Case 1. After the first session of plasmapheresis triglycerides reduced to 1336 mg/dL, after second, to 956 mg/dL and third to 550 mg/dl. She was taken to the ward following the three sessions – plasmaphresis therapy to continue with supportive treatment. After a week on the ward, she was discharged from the hospital with the levels of TG: 278 mg/dL and cholesterol: 181 mg/dL

[Figure ID: F2]
Figure 2 

The change of lipid profile of Case 2 with plasmapheresis therapies. After the first session of plasmapheresis, triglycerides reduced to 1774 mg/dL, amylase to 208 U/L, and lipase to 208 U/L. After the 8th session, triglycerides were 880 mg/dL and she was taken to the ward with continuation of lipidlowering medical therapy. But as TG levels rose again up to 2483 mg/dL under this treatment, six more lasmapheresis sessions were arranged. After the last session, the TG decreased to 570 mg/dL and she needed no more sessions until the delivery of child on 34th gestational week

[TableWrap ID: T1] Table 1 

Initial laboratory data of patients prior to the plasmapheresis treatment

Article Categories:
  • Case Report

Keywords: Acute pancreatitis, plasmapheresis, pregnancy.

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