Document Detail

An alternative method for comparing and describing methacholine response curves.
MedLine Citation:
PMID:  8317786     Owner:  NLM     Status:  MEDLINE    
Tests of nonspecific airway hyperresponsiveness are frequently used in the study of asthma both in the clinical settings and in epidemiologic studies. However, standard methods for characterizing individual tests and comparing results between subgroups have not been established. The most frequently used method of characterizing response curves is to report the dose that results in a 20% fall in FEV1 from the initial or baseline FEV1 value (PD20FEV1). Other investigators have suggested using the response slopes. In this study we demonstrate an alternative method of analysis that uses all of each subject's response data, makes comparisons between subgroups, and can include explanatory covariables. This approach is demonstrated using methacholine challenge data obtained in New Zealand children at 9 and 11 yr of age. The results showed significant differences between the mean dose-response curves of wheezers and nonwheezers, that responsiveness increased with the frequency of reported wheeze, and that initial pulmonary function and serum IgE are significantly related to responsiveness. These factors were not always significant using more traditional methods of analysis, indicating an increased sensitivity with this method of analysis.
D L Sherrill; F D Martinez; M R Sears; M D Lebowitz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  148     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-07-28     Completed Date:  1993-07-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  116-22     Citation Subset:  AIM; IM    
Respiratory Sciences Center, University of Arizona, College of Medicine, Tucson 85724.
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MeSH Terms
Bronchial Provocation Tests / methods*,  statistics & numerical data
Child, Preschool
Dose-Response Relationship, Drug
Forced Expiratory Volume / drug effects
Immunoglobulin E / blood
Logistic Models
Methacholine Chloride / administration & dosage,  diagnostic use*
Random Allocation
Regression Analysis
Respiratory Sounds / diagnosis,  drug effects
Spirometry / statistics & numerical data
Grant Support
Reg. No./Substance:
37341-29-0/Immunoglobulin E; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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