Document Detail


An alternative approach to age adjustment of cancer survival rates.
MedLine Citation:
PMID:  15454258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The measures of cancer prognosis most commonly reported by cancer registries are 5- or 10-year absolute or relative survival rates. Because cancer survival rates often vary by the age of cancer patients, and because the age structure of cancer patients often varies between populations, age adjustment is crucial for comparative analyses of cancer survival rates. However, traditional age adjustment often breaks down for long-term survival rates, particularly for sparse data, and it may provide inconsistent results for relative survival rates, even if age adjustment is made to the study population's own age distribution. In this manuscript, we propose an alternative approach to age adjustment of both absolute and relative survival rates to overcome both the practical and conceptual problems inherent in traditional age adjustment. We outline the computational realisation of this approach, and we give an empirical illustration of its application using data from the nationwide Finnish Cancer Registry.
Authors:
Hermann Brenner; Volker Arndt; Olaf Gefeller; Timo Hakulinen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  40     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-29     Completed Date:  2004-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  2317-22     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D-69115 Heidelberg, Germany. brenner@dzfa.uni-heidelberg.de
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Aged
Humans
Middle Aged
Neoplasms / mortality*
Registries
Survival Analysis
Survival Rate
Time Factors

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