| The alteration and significance of surfactant protein A in rats chronically exposed to cigarette smoke. | |
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MedLine Citation:
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PMID: 18480979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to confirm the alteration and significance of cigarette smoke exposure on SP-A in rats, 20 Wistar rats were assigned randomly to two groups: an N group (n=10), and an S group (n=10). The ultra-structural change was observed by electron microscopy. The number of cells positive for SPA was by immunohistochemically measured. The mRNA expression in the lung tissues was determined by reverse transcription polymerase chain reaction (RT-PCR). The number of cells positive for SPA of the S group (0.52 +/- 0.05) was lower than that of the N group (0.72+/-0.06) (P<0.05). The levels of mRNA of SPA in the lung tissues of the S group (0.3522+/-0.0512) was significantly lower than that of the N group (0.4432+/-0.05628) (P<0.05). It is concluded that cigarette smoke alone decreased the level of SP-A and that might have an important effect on surfactant metabolism and the host defense functions of surfactant in the peripheral airways, which might play a crucial role in the development of chronic obstructive lung disease. |
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Authors:
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Qiongjie Hu; Huilan Zhang; Shengdao Xiong; Xuemei Shi; Yongjian Xu; Zhenxiang Zhang; Guohua Zhen; Jianping Zhao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-15 |
Journal Detail:
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Title: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban Volume: 28 ISSN: 1672-0733 ISO Abbreviation: J. Huazhong Univ. Sci. Technol. Med. Sci. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-05-15 Completed Date: 2008-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101169627 Medline TA: J Huazhong Univ Sci Technolog Med Sci Country: China |
Other Details:
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Languages: eng Pagination: 128-31 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Respiratory Disease of Ministry of Public Health, Wuhan 430030, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Expression Regulation* Immunohistochemistry / methods Lung / metabolism Male Microscopy, Electron Pulmonary Surfactant-Associated Protein A / biosynthesis* RNA, Messenger / metabolism Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Smoking / adverse effects* Tobacco Smoke Pollution / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Pulmonary Surfactant-Associated Protein A; 0/RNA, Messenger; 0/Tobacco Smoke Pollution |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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