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The alteration of placental-derived soluble MHC class I chain-related protein A and B during pregnancy.
MedLine Citation:
PMID:  21426309     Owner:  NLM     Status:  Publisher    
Objective. Mincheva-Nilsson et al. (2006) suggested a novel mechanism for fetal evasion from maternal immune attack in that the engagement and down-regulation of the maternal natural killer cell receptor NKG2D by soluble MHC class I chain-related proteins (sMIC) A and B derived from placenta. Following this report, we aimed to measure if the sMICA/B level altered during pregnancy. Design and Setting. Healthy women undergoing regular ante-partum examination from December 2006 to December 2007 were prospectively registered for this study. Samples. We collected 337 serum specimens and 10 amniotic fluid samples from 300 normal pregnant women for sMICA/B analysis. Methods: Capture ELISA procedures were used to determine sMICA/B concentration in serum and amniotic fluid specimens. Main Outcome Measures. We hypothesized that the sMICA/B level would increase in proportion to the gestational age to protect the fetus from maternal immune rejection in the normal pregnancy. Results. The serum sMICA/B level rose gradually with the progression of gestation and decreased after the third trimester, with the lowest level appearing before delivery. In addition, we found the levels of soluble MICA/B were extremely low in amniotic fluid. Conclusions. We propose the notion that, as delivery approaches, the aged placenta's reduced production of soluble MICA/B may be playing a role in parturition. Furthermore, we suggest the effect of soluble MICA/B on natural killer cells of pregnant women is limited to the maternal placental surface, but not transferred through the placenta into the amniotic cavity.
Shih-Yin Huang; Chi-Hsin Chiang; Fang-Ping Chen; Chia-Li Yu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-23
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors AOGS© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.
Departments of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Keelung Departments of Immunology, National Taiwan Hospital and Institute of Molecular Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
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