Document Detail

The alpha1 isoform of the Na+/K+ ATPase is up-regulated in dedifferentiated progenitor cells that mediate lens and retina regeneration in adult newts.
MedLine Citation:
PMID:  18755185     Owner:  NLM     Status:  MEDLINE    
Adult newts are able to regenerate their retina and lens after injury or complete removal through transdifferentiation of the pigmented epithelial tissues of the eye. This process needs to be tightly controlled, and several different mechanisms are likely to be recruited for this function. The Na(+)/K(+) ATPase is a transmembrane protein that establishes electrochemical gradients through the transport of Na(+) and K(+) and has been implicated in the modulation of key cellular processes such as cell division, migration and adhesion. Even though it is expressed in all cells, its isoform composition varies with cell type and is tightly controlled during development and regeneration. In the present study we characterize the expression pattern of Na(+)/K(+) ATPase alpha1 in the adult newt eye and during the process of lens and retina regeneration. We show that this isoform is up-regulated in undifferentiated cells during transdifferentiation. Such change in composition could be one of the mechanisms that newt cells utilize to modulate this process.
M Natalia Vergara; Laura K Smiley; Katia Del Rio-Tsonis; Panagiotis A Tsonis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-08-08
Journal Detail:
Title:  Experimental eye research     Volume:  88     ISSN:  1096-0007     ISO Abbreviation:  Exp. Eye Res.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-03-16     Completed Date:  2009-06-25     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0370707     Medline TA:  Exp Eye Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  314-22     Citation Subset:  IM    
Department of Zoology, Miami University, Oxford, OH 45056, USA.
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MeSH Terms
Blotting, Western
Lens, Crystalline / chemistry,  metabolism,  physiology*
Protein Isoforms / analysis,  metabolism
Regeneration / physiology*
Retina / chemistry,  metabolism,  physiology*
Salamandridae / metabolism*
Sodium-Potassium-Exchanging ATPase / analysis,  metabolism*
Stem Cells / enzymology*
Grant Support
EY10540/EY/NEI NIH HHS; R01 EY010540/EY/NEI NIH HHS; R01 EY010540-12/EY/NEI NIH HHS
Reg. No./Substance:
0/Protein Isoforms; EC ATPase

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