| PML/RAR alpha(+) hypergranular acute promyelocytic leukemia (M3) developing into an M3 acute myelocytic leukemia without PML/RAR alpha. | |
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MedLine Citation:
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PMID: 11154988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The case of an adult with PML/RARalpha(+) hypergranular acute promyelocytic leukemia (M3) that evolved into a rapidly fatal M3 acute myelocytic leukemia without PML/RARalpha after a complete and molecular remission had been achieved, is presented. Only 7 such cases have been published in the literature. The possible origin of this either leukemic relapse or secondary malignancy is briefly discussed, focusing on the fact that this diagnosis could only be defined by adequate molecular biology studies in the leukemic cells. |
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Authors:
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G J Ruiz-Argüelles; G J Ruiz-Delgado; V Reyes-Núñez |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta haematologica Volume: 104 ISSN: 0001-5792 ISO Abbreviation: Acta Haematol. Publication Date: 2000 |
Date Detail:
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Created Date: 2001-01-26 Completed Date: 2001-03-01 Revised Date: 2006-09-29 |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 124-7 Citation Subset: IM |
Affiliation:
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Centro de Hematología y Medicina Interna de Puebla, Universidad La Salle, México, México. gruiz1@prodigy.net.mx |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Humans Leukemia, Promyelocytic, Acute / drug therapy, genetics*, pathology* Male Neoplasm Proteins / biosynthesis*, genetics Oncogene Proteins, Fusion / biosynthesis*, genetics Pancytopenia / genetics, pathology Receptors, Retinoic Acid / genetics* Recurrence Reverse Transcriptase Polymerase Chain Reaction Tretinoin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins; 0/Oncogene Proteins, Fusion; 0/Receptors, Retinoic Acid; 0/promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; 0/retinoic acid receptor alpha; 302-79-4/Tretinoin |
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