Document Detail

PML/RAR alpha(+) hypergranular acute promyelocytic leukemia (M3) developing into an M3 acute myelocytic leukemia without PML/RAR alpha.
MedLine Citation:
PMID:  11154988     Owner:  NLM     Status:  MEDLINE    
The case of an adult with PML/RARalpha(+) hypergranular acute promyelocytic leukemia (M3) that evolved into a rapidly fatal M3 acute myelocytic leukemia without PML/RARalpha after a complete and molecular remission had been achieved, is presented. Only 7 such cases have been published in the literature. The possible origin of this either leukemic relapse or secondary malignancy is briefly discussed, focusing on the fact that this diagnosis could only be defined by adequate molecular biology studies in the leukemic cells.
G J Ruiz-Argüelles; G J Ruiz-Delgado; V Reyes-Núñez
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta haematologica     Volume:  104     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-03-01     Revised Date:  2006-09-29    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  124-7     Citation Subset:  IM    
Centro de Hematología y Medicina Interna de Puebla, Universidad La Salle, México, México.
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MeSH Terms
Leukemia, Promyelocytic, Acute / drug therapy,  genetics*,  pathology*
Neoplasm Proteins / biosynthesis*,  genetics
Oncogene Proteins, Fusion / biosynthesis*,  genetics
Pancytopenia / genetics,  pathology
Receptors, Retinoic Acid / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Tretinoin / therapeutic use
Reg. No./Substance:
0/Neoplasm Proteins; 0/Oncogene Proteins, Fusion; 0/Receptors, Retinoic Acid; 0/promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; 0/retinoic acid receptor alpha; 302-79-4/Tretinoin

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