| alpha-Glucosidase inhibitory activities of 10-hydroxy-8(E)-octadecenoic acid: an intermediate of bioconversion of oleic acid to 7,10-dihydroxy-8(E)-octadecenoic acid. | |
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MedLine Citation:
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PMID: 20385262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microbial conversion of unsaturated fatty acids often leads to special changes in their product structures and in biological potential. In our continuous effort to screen natural products for their antimicrobial and enzyme inhibitor activities, we found that 10-hydroxy-8(E)-octadecenoic acid (HOD) exhibited strong anti-alpha-glucosidase (EC 3.2.1.20) activity. HOD is an intermediate in the bioconversion of oleic acid to 7,10-dihydroxy-8(E)-octadecenoic acid (DOD) by a bacterial isolate, Pseudomonas aeruginosa (PR3). Diabetes mellitus is the most serious, chronic metabolic disorder characterized by defect in insulin secretion and action, which can lead to damage blood vessels and nerves. We analyzed the inhibitory activity of HOD and the commercially available antidiabetic remedy, acarbose. We found that HOD exhibited a better inhibition (IC(50) 0.07+/-0.12) on alpha-glucosidase as compared to acarbose (IC(50) 0.42+/-0.1). HOD showed competitive inhibition against yeast alpha-glucosidase. Our study is the first report on anti-alpha-glucosidase activity of HOD and could be helpful to develop medicinal preparation or functional food for diabetes and related symptoms. |
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Authors:
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Souren Paul; Ching Tsang Hou; Sun Chul Kang |
Publication Detail:
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Type: Journal Article Date: 2010-04-10 |
Journal Detail:
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Title: New biotechnology Volume: 27 ISSN: 1876-4347 ISO Abbreviation: N Biotechnol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101465345 Medline TA: N Biotechnol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 419-23 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 712-714, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acarbose
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pharmacology Enzyme Inhibitors / pharmacology* Inhibitory Concentration 50 Kinetics Oleic Acids / metabolism*, pharmacology* Pseudomonas aeruginosa / drug effects, metabolism* Saccharomyces cerevisiae / enzymology* Time Factors alpha-Glucosidases / antagonists & inhibitors*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/10-hydroxy-8-octadecenoic acid; 0/7,10-dihydroxy-8-octadecenoic acid; 0/Enzyme Inhibitors; 0/Oleic Acids; 56180-94-0/Acarbose; EC 3.2.1.20/alpha-Glucosidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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