| Is alpha-dystroglycan the missing link in the mechanism of enterocyte uptake and translocation of Mycobacterium avium paratuberculosis? | |
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MedLine Citation:
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PMID: 17597306 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mycobacterium avium paratuberculosis (MAP) is an important animal pathogen with a potential role in human disease. MAP is recognized to cause severe diarrheas and wasting syndrome in patients infected by the human immuno-deficiency virus. Recently, there is also growing evidence that MAP is somehow involved into the patho-mechanisms of Crohn's disease. However, the mechanism how MAP binds to the intestinal mucosa and consecutively invades and translocates the intestinal epithelial cells is still unknown. Here it is suggested, that MAP enters the intestinal cells via the dystrophin-glycoprotein-complex (DGC) in a similar manner as known from Mycobacterium tuberculosis in peripheral Schwann cell invasion. Recent approaches to identify the mechanism of intestinal MAP uptake revealed several molecules which are therefore thought to be involved in MAP cell invasion. Nevertheless, there is no comprehensive connection so far to link all identified mechanisms together. Since the DGC has a direct association to all identified molecules and mechanisms and therefore seems to be the missing link, it is hypothesized now, that MAP binds to alpha-dystroglycan and exploits an endogenous recycling mechanism to control the dystroglycan expression levels to enter and translocate the intestinal cells. Since there are options to modify dystroglycan this might be a potential new target to prevent or even treat intestinal MAP infections. |
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Authors:
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Arne Warth |
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Publication Detail:
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Type: Journal Article Date: 2007-06-26 |
Journal Detail:
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Title: Medical hypotheses Volume: 70 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2008 |
Date Detail:
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Created Date: 2007-12-25 Completed Date: 2008-05-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: Scotland |
Other Details:
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Languages: eng Pagination: 369-74 Citation Subset: IM |
Affiliation:
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Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 220/221, D-69120 Heidelberg, Germany. arne.warth@med.uni-heidelberg.de <arne.warth@med.uni-heidelberg.de> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Crohn Disease / etiology, microbiology Cytoskeleton / metabolism Dystroglycans / physiology* Enterocytes / microbiology*, physiology* Glycoconjugates / metabolism Humans Integrins / metabolism Models, Biological Mycobacterium avium subsp. paratuberculosis / pathogenicity* Paratuberculosis / etiology*, microbiology, physiopathology rho GTP-Binding Proteins / genetics |
| Chemical | |
Reg. No./Substance:
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0/Glycoconjugates; 0/Integrins; 146888-27-9/Dystroglycans; EC 3.6.5.2/rho GTP-Binding Proteins |
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