Document Detail

The alpha-adrenoceptor mediation of the immunomodulatory effects of electroacupuncture in DNP-KLH immunized mice.
MedLine Citation:
PMID:  17669590     Owner:  NLM     Status:  MEDLINE    
Our previous study demonstrated that successive electroacupuncture (EA) at ST36 acupoint reduces IgE production in BALB/c mice immunized with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH) by suppression of the Th2 cell lineage development. Here, we report that pretreatment of phentolamine (alpha-adrenoceptor antagonist, 10mg/kg, i.p.) completely blocks the EA-induced suppression of antigen-specific and total IgE levels in serum and IL-4 production in anti-CD3 mAb-activated splenocytes in DNP-KLH immunized mice. The results suggest that alpha-adrenoceptor play an important role in mediating the suppressive effects of EA on IgE production and Th2 cell response in DNP-KLH immunized mice.
Youngseop Lee; Sun Kwang Kim; Yangseok Kim; Hyejung Lee; Min-Kyu Shin; Moo-Chang Hong; Byung-Il Min; Hyunsu Bae
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-31
Journal Detail:
Title:  Neuroscience letters     Volume:  423     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-22     Completed Date:  2007-11-13     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  149-52     Citation Subset:  IM    
Department of Physiology, College of Oriental Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology
Enzyme-Linked Immunosorbent Assay
Hemocyanin / immunology
Immunoglobulin E / biosynthesis*,  blood
Interferon-gamma / biosynthesis,  immunology
Interleukin-4 / biosynthesis,  immunology
Mice, Inbred BALB C
Phentolamine / pharmacology
Receptors, Adrenergic, alpha / drug effects,  immunology*
Th2 Cells / immunology*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Receptors, Adrenergic, alpha; 207137-56-2/Interleukin-4; 37341-29-0/Immunoglobulin E; 50-60-2/Phentolamine; 82115-62-6/Interferon-gamma; 9013-72-3/Hemocyanin; FV4Y0JO2CX/keyhole-limpet hemocyanin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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