| alpha-Toxin of Staphylococcus aureus overcomes acquired cisplatin-resistance in malignant mesothelioma cells. | |
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MedLine Citation:
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PMID: 18362050 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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alpha-Toxin (alpha-hemolysin) of Staphylococcus aureus is a pore-forming bacterial toxin which after caveolin-1-dependent assembly induces apoptosis in eukaryotic cells. We investigated if a sub-toxic concentration of staphylococcal alpha-toxin could enhance cisplatin-induced apoptosis and overcome acquired cisplatin-resistance in cultured malignant pleural mesothelioma (MPM) cells. MPM cells (P31wt) and a cisplatin-resistant sub-line (P31res) was incubated with alpha-toxin and/or cisplatin followed by determination of cell viability, apoptosis, and signaling pathways. P31res cells were more sensitive to alpha-toxin than P31 wt cells due to induction of apoptosis. A low-toxic concentration of alpha-toxin re-sensitized cisplatin P31res cytotoxicity by apoptosis-induced through the mitochondrial pathway without detectable activation of common up-stream apoptosis signaling proteins. The toxin/drug combination should be tested for cisplatin-resistant mesothelioma treatment. |
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Authors:
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D Johansson; A Johansson; Parviz Behnam-Motlagh |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-24 |
Journal Detail:
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Title: Cancer letters Volume: 265 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-19 Completed Date: 2008-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 67-75 Citation Subset: IM |
Affiliation:
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Department of Medical Biosciences, Clinical Chemistry, Umeå University, Building 6M, 2nd Floor, S-901 85 Umeå, Sweden. david.johansson@medbio.umu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology* Apoptosis Bacterial Toxins / pharmacology* Cell Line, Tumor Cell Survival / drug effects Cisplatin / pharmacology* Drug Resistance, Neoplasm / drug effects* Hemolysin Proteins / pharmacology* Humans Mesothelioma Pleural Neoplasms Signal Transduction Staphylococcus aureus* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Bacterial Toxins; 0/Hemolysin Proteins; 0/staphylococcal alpha-toxin; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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