| alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling. | |
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MedLine Citation:
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PMID: 17825301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Malignant mesothelioma (MM) cells enhanced proliferation of endothelial cells (ECs) as well as their angiogenesis in vitro by secretion of fibroblast growth factor-2 (FGF2). This effect was suppressed by pre-treating MM cells with alpha-tocopheryl succinate (alpha-TOS), which inhibited FGF2 secretion by inducing mitochondria-dependent generation of reactive oxygen species. The role of FGF2 was confirmed by its down-regulation by treating MM cells with siRNA, abolishing EC proliferation and wound healing enhancement afforded by MM cells. We conclude that alpha-TOS disrupts angiogenesis mediated by MM cells by inhibiting FGF2 paracrine signalling. |
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Authors:
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Jiri Neuzil; Emma Swettenham; Xiu-Fang Wang; Lan-Feng Dong; Michael Stapelberg |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-31 |
Journal Detail:
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Title: FEBS letters Volume: 581 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-24 Completed Date: 2007-11-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4611-5 Citation Subset: IM |
Affiliation:
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Apoptosis Research Group, Heart Foundation Research Centre, School of Medical Science, Griffith Institute of Health and Medical Research, Griffith University, Southport 4222, Qld, Australia. j.neuzil@griffith.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Cell Proliferation / drug effects Coculture Techniques Down-Regulation / drug effects Fibroblast Growth Factor 2 / metabolism*, secretion Humans Mesothelioma / blood supply, metabolism, pathology, secretion Paracrine Communication / drug effects* Signal Transduction / drug effects* Tocopherols Vitamin E / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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103107-01-3/Fibroblast Growth Factor 2; 1406-18-4/Vitamin E; 1406-66-2/Tocopherols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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