Document Detail


alpha-Naphthylthiourea produces dose-dependent lung vascular injury in sheep.
MedLine Citation:
PMID:  6812437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We tested the effects of alpha-naphthylthiourea (ANTU) on lung fluid balance and prostanoid concentrations in anesthetized sheep acutely prepared for collection of pulmonary lymph. Sheep were given 20, 50, 75, or 100 mg/kg ANTU or the vehicle dimethylsulfoxide (DMSO) intravenously. The first phase of the response consisted of transient increases in pulmonary artery pressure and plasma and lymph thromboxane B2 concentrations. Lymph flow increased with no change in the lymph-to-plasma protein concentration ratio (L/P). These changes occurred in sheep given DMSO alone or DMSO with ANTU; they were not dependent on the dose of ANTU given. Two to 4 h after drug administration, pulmonary artery pressure and thromboxane concentrations were normal or near normal. Lymph flow rate reached steady-state levels averaging 1.5 (DMSO alone) to 5.3 (100 mg/kg ANTU) times base line with L/P ratios unchanged from base line. ANTU/DMSO produces transient, severe pulmonary hypertension that may be prostaglandin mediated. The sustained response consists of increased flow rate of protein-rich lymph.
Authors:
A M Havill; M H Gee; J D Washburne; A Premkumar; R Ottaviano; J T Flynn; J A Spath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  243     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H505-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dimethyl Sulfoxide / pharmacology
Epoprostenol / pharmacology
Lung / drug effects,  pathology*,  ultrastructure
Microscopy, Electron
Pulmonary Circulation / drug effects*
Rodenticides / toxicity*
Sheep
Thiourea / analogs & derivatives*,  toxicity
Thromboxane B2 / pharmacology
Grant Support
ID/Acronym/Agency:
GM-28023/GM/NIGMS NIH HHS; HL-22911/HL/NHLBI NIH HHS; K04-HL-00601/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Rodenticides; 35121-78-9/Epoprostenol; 54397-85-2/Thromboxane B2; 62-56-6/Thiourea; 67-68-5/Dimethyl Sulfoxide; 86-88-4/alpha-naphthyl thiourea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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