Document Detail


alpha-Methyl-p-tyrosine: a review of its pharmacology and clinical use.
MedLine Citation:
PMID:  7009139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
alpha-Methyl-p-tyrosine is an orally active inhibitor of catecholamine synthesis which inhibits the hydroxylation of tyrosine to dopa. At dosages of 600 to 3500 mg daily it is effective in controlling the hypertensive episodes and symptoms of catecholamine excess in phaeochromocytoma during preparation for surgery. Limited published experience suggests that it is effective in controlling hypertension and symptoms in malignant phaeochromocytoma, but further long term experience is needed. Concomitant administration of phenoxybenzamine and propranolol may be desirable in some patients and treatment with phentolamine is usually necessary to control hypertension during manipulation of the tumour.
Authors:
R N Brogden; R C Heel; T M Speight; G S Avery
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  21     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  81-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Gland Neoplasms / drug therapy
Animals
Blood Pressure / drug effects
Carbohydrate Metabolism
Catecholamines / biosynthesis
Drug Interactions
Humans
Intestinal Absorption
Kinetics
Methyltyrosines / adverse effects,  metabolism,  pharmacology*,  therapeutic use
Pheochromocytoma / drug therapy
alpha-Methyltyrosine
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Methyltyrosines; 658-48-0/alpha-Methyltyrosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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