| alpha-Lipoic acid modulates thiol antioxidant defenses and attenuates exercise-induced oxidative stress in standardbred trotters. | |
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MedLine Citation:
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PMID: 19548154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several micronutrient supplementation strategies are used to cope with oxidative stress, although their benefits have recently been questioned. The aim of the present study was to examine the effects of DL-alpha-lipoic acid (LA) in response to acute exercise and during recovery in horses. Six standardbred trotters were tested on the treadmill before and after 5-week LA supplementation (25 mg/kg body weight/day). According to electron paramagnetic resonance measurements, strenuous aerobic exercise increased significantly free radical formation in the gluteus medius muscle, which was prevented by LA supplementation. The activities of thioredoxin reductase and glutathione reductase in muscle were significantly increased in LA-treated horses, but neither LA nor exercise affected muscle thioredoxin activity. LA increased the concentration of total glutathione in muscle at rest and during recovery. Treatment with LA blunted the exercise-induced increase in plasma oxygen radical absorbance capacity and decreased the post-exercise levels of lipid hydroperoxides in plasma and malondialdehyde in plasma and in muscle. These findings suggest that LA enhances thiol antioxidant defences and decreases exercise-induced oxidative stress in skeletal muscle. |
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Authors:
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Susanna Kinnunen; Niku Oksala; Seppo Hyypp?; Chandan K Sen; Zsolt Radak; David E Laaksonen; Bernadett Szab?; Judit Jakus; Mustafa Atalay |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Free radical research Volume: 43 ISSN: 1029-2470 ISO Abbreviation: Free Radic. Res. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2010-01-19 Completed Date: 2010-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423872 Medline TA: Free Radic Res Country: England |
Other Details:
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Languages: eng Pagination: 697-705 Citation Subset: IM |
Affiliation:
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Institute of Biomedicine, Physiology, University of Kuopio, PO Box 1627, Kuopio, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Supplements* Drug Evaluation, Preclinical / veterinary Electron Spin Resonance Spectroscopy Exercise Test Female Glutathione / metabolism Horses / metabolism* Lipid Peroxidation / drug effects Male Malondialdehyde / analysis Muscle Proteins / metabolism Muscle, Skeletal / drug effects, metabolism Oxidation-Reduction Oxidative Stress* Physical Conditioning, Animal / physiology* Protein Carbonylation / drug effects Reactive Oxygen Species / metabolism Thioctic Acid / pharmacology* Thioredoxins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Muscle Proteins; 0/Reactive Oxygen Species; 52500-60-4/Thioredoxins; 542-78-9/Malondialdehyde; 62-46-4/Thioctic Acid; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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