Document Detail


alpha-Lipoic acid modulates thiol antioxidant defenses and attenuates exercise-induced oxidative stress in standardbred trotters.
MedLine Citation:
PMID:  19548154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several micronutrient supplementation strategies are used to cope with oxidative stress, although their benefits have recently been questioned. The aim of the present study was to examine the effects of DL-alpha-lipoic acid (LA) in response to acute exercise and during recovery in horses. Six standardbred trotters were tested on the treadmill before and after 5-week LA supplementation (25 mg/kg body weight/day). According to electron paramagnetic resonance measurements, strenuous aerobic exercise increased significantly free radical formation in the gluteus medius muscle, which was prevented by LA supplementation. The activities of thioredoxin reductase and glutathione reductase in muscle were significantly increased in LA-treated horses, but neither LA nor exercise affected muscle thioredoxin activity. LA increased the concentration of total glutathione in muscle at rest and during recovery. Treatment with LA blunted the exercise-induced increase in plasma oxygen radical absorbance capacity and decreased the post-exercise levels of lipid hydroperoxides in plasma and malondialdehyde in plasma and in muscle. These findings suggest that LA enhances thiol antioxidant defences and decreases exercise-induced oxidative stress in skeletal muscle.
Authors:
Susanna Kinnunen; Niku Oksala; Seppo Hyypp?; Chandan K Sen; Zsolt Radak; David E Laaksonen; Bernadett Szab?; Judit Jakus; Mustafa Atalay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical research     Volume:  43     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2010-01-19     Completed Date:  2010-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  697-705     Citation Subset:  IM    
Affiliation:
Institute of Biomedicine, Physiology, University of Kuopio, PO Box 1627, Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dietary Supplements*
Drug Evaluation, Preclinical / veterinary
Electron Spin Resonance Spectroscopy
Exercise Test
Female
Glutathione / metabolism
Horses / metabolism*
Lipid Peroxidation / drug effects
Male
Malondialdehyde / analysis
Muscle Proteins / metabolism
Muscle, Skeletal / drug effects,  metabolism
Oxidation-Reduction
Oxidative Stress*
Physical Conditioning, Animal / physiology*
Protein Carbonylation / drug effects
Reactive Oxygen Species / metabolism
Thioctic Acid / pharmacology*
Thioredoxins / analysis
Chemical
Reg. No./Substance:
0/Muscle Proteins; 0/Reactive Oxygen Species; 52500-60-4/Thioredoxins; 542-78-9/Malondialdehyde; 62-46-4/Thioctic Acid; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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