Document Detail

alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria.
MedLine Citation:
PMID:  10401614     Owner:  NLM     Status:  MEDLINE    
In the present cross-sectional study, the influence of alpha-lipoic acid on markers of oxidative stress, assessed by measurement of plasma lipid hydroperoxides (ROOHs), and on the balance between oxidative stress and antioxidant defence, determined by the ratio ROOH/(alpha-tocopherol/cholesterol), was examined in 107 patients with diabetes mellitus. Patients receiving alpha-lipoic acid (600 mg/day for > 3 months) had significant lower ROOHs and a lower ROOH/(alpha-tocopherol/cholesterol) ratio than those without alpha-lipoic acid treatment [ROOH: 4.76 +/- 2.49 vs. 7.16 +/- 3.22 mumol/l; p < .0001] and [ROOH/(alpha-tocopherol/cholesterol): 1.37 +/- 0.72 vs. 2.16 +/- 1.17; p < 0.0001]. In addition, the influence of glycemic control and albuminuria on ROOHs and on the ratio of ROOH/(alpha-tocopherol/cholesterol) was examined in the presence and absence of alpha-lipoic acid treatment. Patients were subdivided into three groups based on (1) their HbA1 levels (< 7.5, 7.5-9.5, and > 9.5%) and (2) their urinary albumin concentrations (< 20, 20-200, and > 200 mg/l). Neither poor glycemic control, nor the presence of micro- or macroalbuminuria prevented the antioxidant effect of alpha-lipoic acid. Using stepwise multiple regression analysis, alpha-lipoic acid was found to be the only factor significantly predicting low ROOHs and a low ratio of ROOH/(alpha-tocopherol/cholesterol). These data provide evidence that treatment with alpha-lipoic acid improves significantly the imbalance between increased oxidative stress and depleted antioxidant defence even in patients with poor glycemic control and albuminuria.
V Borcea; J Nourooz-Zadeh; S P Wolff; M Klevesath; M Hofmann; H Urich; P Wahl; R Ziegler; H Tritschler; B Halliwell; P P Nawroth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  26     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-09-16     Completed Date:  1999-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1495-500     Citation Subset:  IM    
Department of Internal Medicine I, University of Heidelberg, Germany.
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MeSH Terms
Albuminuria / drug therapy*
Antioxidants / metabolism
Blood Glucose / metabolism*
Cross-Sectional Studies
Diabetes Mellitus, Type 2 / drug therapy*,  metabolism
Hemoglobin A, Glycosylated / metabolism
Lipid Peroxides / blood
Middle Aged
Oxidative Stress / drug effects*
Regression Analysis
Thioctic Acid / therapeutic use*
Reg. No./Substance:
0/Antioxidants; 0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Lipid Peroxides; 62-46-4/Thioctic Acid

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