| alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. | |
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MedLine Citation:
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PMID: 10401614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present cross-sectional study, the influence of alpha-lipoic acid on markers of oxidative stress, assessed by measurement of plasma lipid hydroperoxides (ROOHs), and on the balance between oxidative stress and antioxidant defence, determined by the ratio ROOH/(alpha-tocopherol/cholesterol), was examined in 107 patients with diabetes mellitus. Patients receiving alpha-lipoic acid (600 mg/day for > 3 months) had significant lower ROOHs and a lower ROOH/(alpha-tocopherol/cholesterol) ratio than those without alpha-lipoic acid treatment [ROOH: 4.76 +/- 2.49 vs. 7.16 +/- 3.22 mumol/l; p < .0001] and [ROOH/(alpha-tocopherol/cholesterol): 1.37 +/- 0.72 vs. 2.16 +/- 1.17; p < 0.0001]. In addition, the influence of glycemic control and albuminuria on ROOHs and on the ratio of ROOH/(alpha-tocopherol/cholesterol) was examined in the presence and absence of alpha-lipoic acid treatment. Patients were subdivided into three groups based on (1) their HbA1 levels (< 7.5, 7.5-9.5, and > 9.5%) and (2) their urinary albumin concentrations (< 20, 20-200, and > 200 mg/l). Neither poor glycemic control, nor the presence of micro- or macroalbuminuria prevented the antioxidant effect of alpha-lipoic acid. Using stepwise multiple regression analysis, alpha-lipoic acid was found to be the only factor significantly predicting low ROOHs and a low ratio of ROOH/(alpha-tocopherol/cholesterol). These data provide evidence that treatment with alpha-lipoic acid improves significantly the imbalance between increased oxidative stress and depleted antioxidant defence even in patients with poor glycemic control and albuminuria. |
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Authors:
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V Borcea; J Nourooz-Zadeh; S P Wolff; M Klevesath; M Hofmann; H Urich; P Wahl; R Ziegler; H Tritschler; B Halliwell; P P Nawroth |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Free radical biology & medicine Volume: 26 ISSN: 0891-5849 ISO Abbreviation: Free Radic. Biol. Med. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-09-16 Completed Date: 1999-09-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1495-500 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine I, University of Heidelberg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albuminuria
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drug therapy* Antioxidants / metabolism Blood Glucose / metabolism* Cross-Sectional Studies Diabetes Mellitus, Type 2 / drug therapy*, metabolism Female Hemoglobin A, Glycosylated / metabolism Humans Lipid Peroxides / blood Male Middle Aged Oxidative Stress / drug effects* Regression Analysis Thioctic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Lipid Peroxides; 62-46-4/Thioctic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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