Document Detail

Alpha-lactalbumin-enriched and probiotic-supplemented infant formula in infants with colic: growth and gastrointestinal tolerance.
MedLine Citation:
PMID:  20517331     Owner:  NLM     Status:  MEDLINE    
Studies undertaken with alpha-lactalbumin-enriched formulae never addressed infants with colic. This study evaluated the nutritional adequacy, the gastrointestinal tolerance and the effect on colic of an alpha-lactalbumin-enriched and probiotic-supplemented formula. A double-blind, placebo-controlled study enrolled 66 healthy infants with colic, aged 3 weeks to 3 months, fed during 1 month with the either experimental formula (EF, Modilac Digest 1) or control formula (CF) and evaluated for efficacy and safety parameters at days 15 and 30. Weight and height gains were identical in the two groups and complied with standards (1023.4+/-360.4 g (EF) and 1047.4+/-372.1 g (CF), NS; 4.2+/-1.4 cm (EF) and 4.3+/-1.9 cm (CF), NS). No differences were found between groups for crying duration. 'Feeding-related' gastrointestinal side effects were significantly lower with EF than with CF (P=0.011). An alpha-lactalbumin-enriched and probiotic-supplemented formula guaranteed good weight and length gains to infants with colic and seemed to provide good gastrointestinal tolerance.
C Dupont; M Rivero; C Grillon; N Belaroussi; A Kalindjian; V Marin
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-06-02
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  64     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-07     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  765-7     Citation Subset:  IM    
Service de Néonatologie et Nutrition, Hôpital St Vincent de Paul, Université Paris Descartes, Paris, France.
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MeSH Terms
Colic / therapy*
Dietary Supplements*
Double-Blind Method
Gastrointestinal Diseases / therapy*
Growth / drug effects*
Infant Formula*
Lactalbumin / adverse effects,  therapeutic use*
Probiotics / therapeutic use*
Prospective Studies
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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