Document Detail

alpha-Hydroxy acid-based cosmetic procedures. Guidelines for patient management.
MedLine Citation:
PMID:  11702315     Owner:  NLM     Status:  MEDLINE    
alpha-Hydroxy acid (AHA) peels and home regimens have recently been recognized as important adjunctive therapy in a variety of conditions including photodamage, actinic damage, melasma, hyperpigmentation disorders, acne, and rosacea. Overall in our experience and in the literature, AHAs have a proven level of safety and efficacy in a variety of skin types. Although their exact mechanism of action is unknown, it has been demonstrated that AHAs improve these disorders by thinning the stratum corneum, promoting epidermolysis, dispersing basal layer melanin, and increasing collagen synthesis within the dermis. In patients with photodamage, AHA peels and topical products are often combined with retinoids and other antioxidants for maximum benefit. Similarly, synergistic effects of fluorouracil and glycolic acid are observed in the treatment of diffuse actinic keratoses. For patients with melasma, AHA peels and combination products containing bleaching agents such as hydroquinone, kojic acid, and glycolic acid seem to have increased efficacy. Acne and rosacea patients can see improved results when standard regimens like antibacterials and topical retinoids are supplemented with AHA peels and lotions. However, care should always be taken prior to commencing treatment with AHA peels and topical products. By obtaining a thorough history and physical examination, the physician will identify any specific factors like medications, prior procedures and medical conditions which can affect the outcome of the peel. During the interview, there should be open discussion of patient questions and concerns so that realistic expectations can be made. Pre- and post-peel regimens should also be reviewed in full as patient compliance is essential to ensure the success of a series of AHA peels.
R C Tung; W F Bergfeld; A T Vidimos; B K Remzi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of clinical dermatology     Volume:  1     ISSN:  1175-0561     ISO Abbreviation:  Am J Clin Dermatol     Publication Date:    2000 Mar-Apr
Date Detail:
Created Date:  2001-11-12     Completed Date:  2002-07-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100895290     Medline TA:  Am J Clin Dermatol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Cleveland Clinic Foundation, Department of Dermatology, Cleveland, Ohio, USA.
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MeSH Terms
Acne Vulgaris / drug therapy
Clinical Protocols
Hydroxy Acids / pharmacology,  therapeutic use*
Keratosis / drug therapy
Rosacea / drug therapy
Skin Aging / drug effects
Skin Diseases / drug therapy*
Reg. No./Substance:
0/Hydroxy Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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