Document Detail

alpha-Fetoprotein levels of paired samples between the amniotic fluid and maternal serum from 16 to 18 weeks' gestation in Chinese women.
MedLine Citation:
PMID:  7522692     Owner:  NLM     Status:  MEDLINE    
To assess the relationship between alpha-fetoprotein (AFP) concentrations of amniotic fluid and maternal serum from 16 to 18 weeks' gestation, 890 paired samples of maternal serum and amniotic fluid were collected from women with normal singleton pregnancies. The gestational age was determined by ultrasonographic dating before amniocentesis, and the AFP measurements were performed by a single reference laboratory. There was a significant rise in the maternal serum AFP (MSAFP) concentration from 16 to 18 weeks' gestation. Amniotic fluid AFP concentrations significantly declined from 16 to 18 weeks' gestation. This study failed to demonstrate any statistical relationship between the AFP concentration of maternal serum and amniotic fluid (r = 0.031). This finding indicates that amniotic fluid AFP levels cannot be predicted by MSAFP levels between 16 and 18 weeks' gestation. Simple diffusion may not be the only mechanism for the transfer of AFP through the fetal membrane to maternal circulation.
J J Hsu; T T Hseih; T H Chiu; J D Liou; Y K Soong
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  93     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-11-22     Completed Date:  1994-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  374-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan R.O.C.
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MeSH Terms
Amniotic Fluid / chemistry*
Predictive Value of Tests
Pregnancy Trimester, Second / blood
alpha-Fetoproteins / analysis*
Reg. No./Substance:

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