Document Detail


The alpha 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta.
MedLine Citation:
PMID:  7674815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pA2 value of several alpha 1-adrenoceptor antagonists on noradrenaline-induced contractions of rat aorta, and their affinity for the cloned alpha 1a-, alpha 1b- and alpha 1d-adrenoceptor subtypes were evaluated. Selective or moderately selective alpha 1d-, partially selective alpha 1b-, selective alpha 1a- and non subtype-selective alpha 1-adrenoceptors antagonists were included in the study. The potency of these compounds on rat aorta was well correlated with the affinity observed for the alpha 1d-adrenoceptor subtype. A poor correlation was found for the alpha 1b- and alpha 1a-subtypes. These results suggest that the alpha 1d-subtype plays a determining role in rat aorta contractions induced by noradrenaline.
Authors:
R Testa; C Destefani; L Guarneri; E Poggesi; I Simonazzi; C Taddei; A Leonardi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  57     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1995  
Date Detail:
Created Date:  1995-10-19     Completed Date:  1995-10-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  PL159-63     Citation Subset:  IM    
Affiliation:
Research & Development Department, RECORDATI S.p.A., Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / pharmacology
Animals
Aorta / physiology*
Ligands
Male
Muscle Contraction / drug effects,  physiology*
Muscle, Smooth, Vascular / drug effects,  physiology*
Norepinephrine / pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, alpha-1 / classification,  physiology*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Ligands; 0/Receptors, Adrenergic, alpha-1; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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