Document Detail


The alloantibody response and active enhancement of some rat renal allografts.
MedLine Citation:
PMID:  324043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lewis rats that were given injections of 10(6) to 10(8) (Lewis X Brown Norway) F1 hybrid bone marrow cells produce predominantly, if not exclusively, 19S lymphocytotoxic antibodies. A number of Lewis rats that received transplants of perfused renal allografts from bone marrow donors at, or near, the peak of IgM response survival for well over 200 days with good renal function and no histological evidence of chronic rejection. All long-surviving rats had detectable lymphocytotoxic antibodies up to 120 days after allografting; late enhancing antibodies had the restricted specificity possibly identical or similar to anti-I region antisera. All rats bearing prolonged renal allografts were unable to accept donor-specific skin grafts or to respond with specific lymphocytotoxic antibodies following skin grafting. The possible involvement of non-complement-fixing 19S alloantibodies in active enhancement of rat renal allografts is discussed.
Authors:
S B Desi; M Ruszkiewicz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  23     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-06-11     Completed Date:  1977-06-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  230-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow / immunology
Bone Marrow Cells*
Bone Marrow Transplantation*
Cytotoxicity Tests, Immunologic
Female
Graft Rejection
Graft Survival
Immunization
Isoantibodies / biosynthesis*
Kidney / immunology,  physiology
Kidney Transplantation*
Male
Rats
Rats, Inbred Lew
Skin Transplantation
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Isoantibodies

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