Document Detail

The allergic march: can we prevent allergies and asthma?
MedLine Citation:
PMID:  21621060     Owner:  NLM     Status:  In-Data-Review    
The allergic march is a progression of atopic disease from eczema to asthma, and then to allergic rhinoconjunctivitis. It appears to be caused by a regional allergic response with breakdown of the local epithelial barrier that initiates systemic allergic inflammation. Genetic and environmental factors predispose to developing the allergic march. There are data to support 4 possible interventions to prevent the allergic march from progressing to asthma: (1) supplements of dietary probiotics, (2) exclusive breast feeding during the first few months of life, or, alternatively (3) use of extensively hydrolyzed infant formulas, (4) treatment with inhalant allergen immunotherapy by either subcutaneous or sublingual methods.
Bruce R Gordon
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otolaryngologic clinics of North America     Volume:  44     ISSN:  1557-8259     ISO Abbreviation:  Otolaryngol. Clin. North Am.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0144042     Medline TA:  Otolaryngol Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  765-77     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Surgery, Cape Cod Hospital, 27 Park Street, Hyannis, MA 02601, USA; Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA; Department of Laryngology and Otology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
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