Document Detail

The alkaline shift in gastric pH after cholecystectomy.
MedLine Citation:
PMID:  2910128     Owner:  NLM     Status:  MEDLINE    
Previous studies using cholescintigraphy and measurement of bile salts in gastric juice have demonstrated that duodenogastric reflux is increased after cholecystectomy, a factor that may contribute to postoperative complaints in some patients. We studied 24-hour continuous gastric pH in healthy subjects, patients with cholelithiasis, and patients who had undergone cholecystectomy. Cholecystectomy decreased the percentage of time that gastric pH is below 2 and increased the time it is above 4 and 6. Furthermore, there was a greater increase in the more alkaline pH values in patients who were symptomatic than in those who were asymptomatic. The results demonstrated that cholecystectomy is associated with an alkaline shift in the 24-hour gastric pH profile that is most marked in symptomatic patients. This suggests that gastric alkaline episodes may be related to some postcholecystectomy symptoms.
T H Brown; G Walton; W G Cheadle; G M Larson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  157     ISSN:  0002-9610     ISO Abbreviation:  Am. J. Surg.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  58-65     Citation Subset:  AIM; IM    
Department of Surgery, University of Louisville, Kentucky 40292.
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MeSH Terms
Cholelithiasis / physiopathology*
Duodenogastric Reflux / metabolism*
Gastric Acidity Determination*
Hydrogen-Ion Concentration
Middle Aged
Monitoring, Physiologic
Postoperative Complications / metabolism*

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