Document Detail

An algorithm to predict implantable cardioverter-defibrillator lead failure.
MedLine Citation:
PMID:  15519026     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The goal of this analysis was to test an algorithm that identifies implantable cardioverter-defibrillator (ICD) lead problems before clinical failure and/or inappropriate therapy. BACKGROUND: The ICD lead failures typically present as inappropriate shock therapy. Identifying lead failures before their clinical presentation may prevent patient discomfort, improve device longevity, and avoid device-induced proarrhythmia. METHODS: We tested an algorithm that uses two measures of oversensing and one measure of abnormal impedance to detect a lead failure. The oversensing measures consisted of a counter for RR intervals <140 ms and nonsustained ventricular tachycardia episodes with mean RR interval <200 ms. The impedance measure tracked lead impedances every day and each week. Abnormal impedance was defined as a decrease in impedances or an outlier value compared with baseline. Lead failures were identified when both oversensing measures were met or abnormal impedance and one oversensing measure occurred. The stored data from 696 patients with an ICD were analyzed to determine the sensitivity and specificity of the algorithm to detect lead failures. RESULTS: Twenty-nine patients demonstrated clinical lead failures with an average of 6 +/- 9 inappropriate shocks per patient. The two oversensing measures used in the algorithm predicted 72% (21 of 29) of the lead failures. Fulfilling at least two of the three impedance and oversensing measures, the sensitivity of our algorithm was 83% (24 of 29) with a 100% (667 of 667) specificity. CONCLUSION: Oversensing combined with abnormal impedance trends may be used to identify ICD lead failures with high sensitivity and very high specificity.
Bruce D Gunderson; Amisha S Patel; Chad A Bounds; Richard K Shepard; Mark A Wood; Kenneth A Ellenbogen
Related Documents :
22095736 - Regeneration of the heart.
15250866 - Effect of rapid biphasic shock subpulse switching on ventricular defibrillation thresho...
380436 - Bretylium tosylate: a newly available antiarrhythmic drug for ventricular arrhythmias.
25318986 - Noninvasive measurement and clinical relevance of myocardial twist and torsion.
21703366 - The role of mitochondrial membrane potential in ischemic heart failure.
9285656 - Comparison of degrees of left ventricular dilation within three hours and up to six day...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  44     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-02     Completed Date:  2005-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1898-902     Citation Subset:  AIM; IM    
Medtronic, Inc., Minneapolis, Minnesota, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Defibrillators, Implantable*
Electric Countershock
Electric Impedance
Equipment Failure
False Positive Reactions
Follow-Up Studies
Heart Conduction System / pathology,  surgery
Predictive Value of Tests
Sensitivity and Specificity
Tachycardia, Ventricular / diagnosis,  therapy
Time Factors
Ventricular Fibrillation / diagnosis,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Beat-to-beat analysis of pressure wave morphology for pre-symptomatic detection of orthostatic intol...
Next Document:  Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy.