| An algorithm for preventing bypass-associated dilutional (BAD) coagulopathy: Theory and example. | |
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MedLine Citation:
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PMID: 20427210 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Crystalloid administered during cardiopulmonary bypass may significantly dilute clotting factor concentrations, particularly in low blood volume patients. Should the administered fluid (pump prime plus IVs) drop the clotting factor concentrations below approximately 38%, almost all patients will bleed, heparin levels will be overestimated and excessive neutralizing protamine will be administered. This combination can render blood virtually unclottable. This paper describes algorithms that quantify dilution risk and the maximum fluid that can be safely administered. A confirmatory calculation to prevent excessive protamine administration is also described. |
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Authors:
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Paul C Herrmann; Karen L Hay; Brian S Bull |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-27 |
Journal Detail:
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Title: Blood cells, molecules & diseases Volume: 45 ISSN: 1096-0961 ISO Abbreviation: Blood Cells Mol. Dis. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509932 Medline TA: Blood Cells Mol Dis Country: United States |
Other Details:
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Languages: eng Pagination: 98-101 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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School of Medicine, Department of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA 92350, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Blood Coagulation Disorders / prevention & control* Cardiopulmonary Bypass* Female Humans Isotonic Solutions / administration & dosage*, adverse effects Middle Aged Protamines / administration & dosage*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Isotonic Solutions; 0/Protamines; 0/crystalloid solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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