Document Detail


An algorithm for the estimation of gestational age at the time of fetal death.
MedLine Citation:
PMID:  23374059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Accurate assignment of gestational age (GA) at time of fetal death is important for research and clinical practice. An algorithm to estimate GA at fetal death was developed and evaluated.
METHODS: The algorithm developed by the Stillbirth Collaborative Research Network (SCRN) incorporated clinical and post-mortem data. The SCRN conducted a population-based case-control study of women with stillbirths and livebirths from 2006 to 2008 in five geographical catchment areas. Rules were developed to estimate a due date, identify an interval during which death likely occurred, and estimate GA at the time of fetal death. Reliability of using fetal foot length to estimate GA at death was assessed.
RESULTS: The due date estimated for 620 singleton stillbirths studied was considered clinically reliable for 87%. Only 25.2% of stillbirths were documented alive within 2 days before diagnosis and 47.6% within 1 week of diagnosis. The algorithm-derived estimate of GA at time of fetal death was one or more weeks earlier than the GA at delivery for 43.5% of stillbirths. GA estimated from fetal foot length agreed with GA by algorithm within 2 weeks for 75% within a subset of well-dated stillbirths.
CONCLUSIONS: Precise assignment of GA at death, defined as reliable dating criteria and a short interval (≤1 week) during which fetal death was known to have occurred, was possible in 46.6% of cases. Fetal foot length is a relatively accurate measure of GA at death and should be collected in all stillbirth cases.
Authors:
Deborah L Conway; Nellie I Hansen; Donald J Dudley; Corette B Parker; Uma M Reddy; Robert M Silver; Radek Bukowski; Halit Pinar; Barbara J Stoll; Michael W Varner; George R Saade; Carol Hogue; Marian Willinger; Donald Coustan; Matthew A Koch; Robert L Goldenberg;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  27     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-08-01     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  145-57     Citation Subset:  IM    
Copyright Information:
© 2013 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Algorithms*
Female
Fetal Death*
Gestational Age*
Humans
Predictive Value of Tests
Pregnancy
Reproducibility of Results
Stillbirth / epidemiology*
Grant Support
ID/Acronym/Agency:
U01-HD045954/HD/NICHD NIH HHS; U10 HD045955/HD/NICHD NIH HHS; U10-HD045925/HD/NICHD NIH HHS; U10-HD045944/HD/NICHD NIH HHS; U10-HD045952/HD/NICHD NIH HHS; U10-HD045953/HD/NICHD NIH HHS; U10-HD045955/HD/NICHD NIH HHS
Investigator
Investigator/Affiliation:
Donald J Dudley / ; Deborah Conway / ; Josefine Heim-Hall / ; Karen Aufdemorte / ; Angela Rodriguez / ; Robert M Silver / ; Michael W Varner / ; Kristi Nelson / ; Carol J Rowland Hogue / ; Barbara J Stoll / ; Janice Daniels Tinsley / ; Bahig Shehata / ; Carlos Abramowsky / ; Donald Coustan / ; D L Conway / ; Halit Pinar / ; Marshall Carpenter / ; Susan Kubaska / ; George R Saade / ; Radek Bukowski / ; Jennifer Lee Rollins / ; Hal Hawkins / ; Elena Sbrana / ; Corette B Parker / ; Matthew A Koch / ; Vanessa R Thorsten / ; Holly Franklin / ; Pinliang Chen / ; Marian Willinger / ; Uma M Reddy / ; Robert L Goldenberg /
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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