| The aldehydic metabolites of linoleic acid are cytotoxic against human breast cancer cells. | |
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MedLine Citation:
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PMID: 1946549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cytotoxic effect of aldehydic metabolites of linoleic acid, 13-oxo-tridecadienoic acids, on MCF-7 human breast cancer cells was investigated. The metabolites inhibited the growth of the cancer cells and the effect was dependent on both time of exposure and concentration of the metabolites; 50% growth inhibition occurred at approximately 55 and 33 microM, after 3- and 5-day incubations, respectively. The metabolites had greater cytotoxicity than parent linoleic acid or other polyunsaturated fatty acids tested. The antiproliferative effect was partially reversed by 10 microM of dithiothreitol suggesting that attack on thiol groups in cancer cells by highly reactive alpha, beta-unsaturated carbonyl moiety in the metabolites was responsible for the cytotoxic actions. |
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Authors:
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R S Kim; C L Zaborniak |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 43 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-12-13 Completed Date: 1991-12-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 223-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Therapeutics, University of Manitoba, Faculty of Medicine, Winnipeg, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes
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metabolism,
pharmacology Breast Neoplasms / drug therapy Cell Division / drug effects Dithiothreitol / pharmacology Fatty Acids, Unsaturated / metabolism, pharmacology Female Humans Linoleic Acid Linoleic Acids / metabolism*, pharmacology* Tumor Cells, Cultured / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 2197-37-7/Linoleic Acid; 3483-12-3/Dithiothreitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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