Document Detail


The aldehydic metabolites of linoleic acid are cytotoxic against human breast cancer cells.
MedLine Citation:
PMID:  1946549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cytotoxic effect of aldehydic metabolites of linoleic acid, 13-oxo-tridecadienoic acids, on MCF-7 human breast cancer cells was investigated. The metabolites inhibited the growth of the cancer cells and the effect was dependent on both time of exposure and concentration of the metabolites; 50% growth inhibition occurred at approximately 55 and 33 microM, after 3- and 5-day incubations, respectively. The metabolites had greater cytotoxicity than parent linoleic acid or other polyunsaturated fatty acids tested. The antiproliferative effect was partially reversed by 10 microM of dithiothreitol suggesting that attack on thiol groups in cancer cells by highly reactive alpha, beta-unsaturated carbonyl moiety in the metabolites was responsible for the cytotoxic actions.
Authors:
R S Kim; C L Zaborniak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  43     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-13     Completed Date:  1991-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  223-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics, University of Manitoba, Faculty of Medicine, Winnipeg, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aldehydes / metabolism,  pharmacology
Breast Neoplasms / drug therapy
Cell Division / drug effects
Dithiothreitol / pharmacology
Fatty Acids, Unsaturated / metabolism,  pharmacology
Female
Humans
Linoleic Acid
Linoleic Acids / metabolism*,  pharmacology*
Tumor Cells, Cultured / drug effects*
Chemical
Reg. No./Substance:
0/Aldehydes; 0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 2197-37-7/Linoleic Acid; 3483-12-3/Dithiothreitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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