Document Detail


The alcohol syndromes: the intrarecombigenic effect of acetaldehyde.
MedLine Citation:
PMID:  624349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sister chromatid exchange was studied in lymphocyte and fibroblast cultures. Alcohol caused no disturbance under normal conditions but an acetaldehyde level above 40 muM inhibited cell multiplication and elevated SCE considerably. A high acetaldehyde level is thought to elicit the fetal alcohol syndrome, a view supported by clinical and experimental observations.
Authors:
P V Véghelyi; M Osztovics
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experientia     Volume:  34     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  195-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaldehyde / pharmacology*
Alcoholism / blood,  genetics*
Cells, Cultured
Chromatids / drug effects
Disulfiram / pharmacology
Ethanol / blood
Humans
Lymphocytes / drug effects,  metabolism,  ultrastructure
Mitotic Index / drug effects
Recombination, Genetic*
Chemical
Reg. No./Substance:
64-17-5/Ethanol; 75-07-0/Acetaldehyde; 97-77-8/Disulfiram

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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