Document Detail

The alcohol syndromes: the intrarecombigenic effect of acetaldehyde.
MedLine Citation:
PMID:  624349     Owner:  NLM     Status:  MEDLINE    
Sister chromatid exchange was studied in lymphocyte and fibroblast cultures. Alcohol caused no disturbance under normal conditions but an acetaldehyde level above 40 muM inhibited cell multiplication and elevated SCE considerably. A high acetaldehyde level is thought to elicit the fetal alcohol syndrome, a view supported by clinical and experimental observations.
P V Véghelyi; M Osztovics
Related Documents :
6155609 - Frequencies of sister-chromatid exchanges in relation to cell kinetics in lymphocyte cu...
16483569 - Chromosomal damage and atherosclerosis. a protective effect from simvastatin.
16309949 - Evaluation of genotoxic effects of apitol (cymiazole hydrochloride) in vitro by measure...
9434859 - Thalidomide: lack of mutagenic activity across phyla and genetic endpoints.
2911259 - Effects of 50-hertz electromagnetic fields on proliferation and on chromosomal alterati...
6617599 - The mutagenic activity of 5-bromo-2'-deoxyuridine (brdu) in vivo in rats.
19002959 - Culturing and differentiation of murine embryonic stem cells in a three-dimensional fib...
3720689 - Characterization of human pulmonary endocrine cells maintained in vitro.
22754019 - Studies on non-symbiotic diazotrophic bacterial populations of coastal arable saline so...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experientia     Volume:  34     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  195-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetaldehyde / pharmacology*
Alcoholism / blood,  genetics*
Cells, Cultured
Chromatids / drug effects
Disulfiram / pharmacology
Ethanol / blood
Lymphocytes / drug effects,  metabolism,  ultrastructure
Mitotic Index / drug effects
Recombination, Genetic*
Reg. No./Substance:
64-17-5/Ethanol; 75-07-0/Acetaldehyde; 97-77-8/Disulfiram

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biotin as a regulator of some haematic parameters and of DNA-content of the liver of old rats.
Next Document:  Distension of the reticulum decreased food but not water intake by sheep.