Document Detail


The alchemy of immune privilege explored from a neuroimmunological perspective.
MedLine Citation:
PMID:  18603017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The term 'immune privilege' (IP) generally describes the protection of vital structures, such as the brain, the eye, or the pregnant uterus, from the potentially damaging effects of an inflammatory immune response. Initially, barriers physically camouflaging such organs were thought to shield autoantigens from immune recognition and inflammation. This simplistic concept gave way to a much more complex understanding of IP, which reflects an entire network of interacting immunoregulatory processes and immunosuppressive microenvironments. Also, the number of organs and tissues that enjoy relative IP has grown considerably. This is not surprising since many different organs are constantly exposed to major, potentially damaging inflammatory events, for example, skin, gut, or lung-without evidence for excessive inflammation under physiological conditions. Focusing on fetotrophoblast IP as well as on hair-follicle-associated IP (an underappreciated, yet biologically fascinating, clinically important IP model), we summarize here key regulatory cues that operate in immunoprivileged tissues. Proposing novel concepts of how IP may collapse, for example, by exposure to psychosocial, stress-associated inflammation, we develop related strategies for how IP may be manipulated clinically so as to achieve IP protection and restoration.
Authors:
Petra Clara Arck; Amos Gilhar; John Bienenstock; Ralf Paus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-07-28
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  8     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-10-13     Completed Date:  2009-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  480-9     Citation Subset:  IM    
Affiliation:
The Brain-Body Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. petra.arck@charite.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Immune System / physiology*
Nervous System Physiological Phenomena / immunology*
Stress, Psychological / immunology

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