Document Detail

Is albumin administration beneficial in early stage of postoperative hypoalbuminemia following gastrointestinal surgery?: a prospective randomized controlled trial.
MedLine Citation:
PMID:  18649869     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Surgeons commonly see postoperative hypoalbuminemia, but whether exogenous albumin administration is beneficial for these patients is unclear. METHODS: A prospective, randomized study design was used, allocating 127 hypoalbuminemic patients into the albumin or saline group after gastrointestinal surgery. We investigated the development of postoperative hypoalbuminemia, nutritional status, postoperative fluid balance, postoperative complications, and postoperative hospital stay. RESULTS: Plasma albumin concentrations of both groups decreased after operations (P <.01). No significant differences were found between groups (P >.05) in changes in postoperative plasma albumin concentration from baseline levels. Postoperative plasma albumin, total protein, and prealbumin levels were similar in the 2 groups. While 3-day and 5-day recovery ratios were similar, 7-day recovery ratios were lower in the albumin group (P <.05). No significant difference was found in overall fluid administration, urine output, or the incidence of postoperative complications between groups (23.4% for albumin group and 12.7% for control group, P = .116). CONCLUSIONS: Albumin administration in the early stage of postoperative hypoalbuminemia following gastrointestinal surgery is not beneficial in correcting hypoalbuminemia or in clinical outcomes.
Xi-Yu Yuan; Chang-Hua Zhang; Yu-Long He; Yan-Xian Yuan; Shi-Rong Cai; Ning-Xiang Luo; Wen-Hua Zhan; Ji Cui
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-07-23
Journal Detail:
Title:  American journal of surgery     Volume:  196     ISSN:  1879-1883     ISO Abbreviation:  Am. J. Surg.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-28     Completed Date:  2008-12-16     Revised Date:  2009-10-05    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  751-5     Citation Subset:  AIM; IM    
Department Gastro-intestinal Pancreatic Surgery, Centre of Gastric Cancer, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China 510080.
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MeSH Terms
Aged, 80 and over
Albumins / administration & dosage*
Chi-Square Distribution
Digestive System Surgical Procedures
Hypoalbuminemia / drug therapy*
Middle Aged
Postoperative Complications / drug therapy*
Prospective Studies
Treatment Outcome
Reg. No./Substance:
Comment In:
Am J Surg. 2009 Oct;198(4):582   [PMID:  19345334 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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